摘要
一系列新奇氟化的 thieno [2,3-d ] 合并 1,3,4-thiadiazole 的嘧啶衍生物被一个灵巧的帮助微波的过程综合包括有 trifluoroacetic 酸的 2-aminothiophene-3-carbonitrile 的环合,氯化和亲核的替换反应。这个协议提供了象温和反应条件,短反应时间,简单纯化和好收益的如此的优点。产品的结构被 1H NMR, MS,元素的分析和 X 光检查衍射描绘。
A series of novel fluorinated thieno[2,3-d]pyrimidine derivatives incorporating 1,3,4-thiadiazole were synthesized by a facile microwave-assisted procedure,including the cyclization of 2-aminothiophene-3-carbonitrile with trifluoroacetic acid,chlorination and nucleophilic substitution reaction.This protocol offered such advantages as mild reaction conditions,short reaction time, simple puritication and good yields.The structures of the products were characterized by ~1H NMR,MS,elemental analysis and Xray diffraction.
基金
the Natural Science Foundation of Hubei Province(No2011CDB087)
Scientific Research Fund of Hubei Provincial Education Department(NoD20111904)
Open Fund of Key Laboratory of Biological Resources Protection and Utilization of Hubei Province(NoPKLHB1102)for generous financial support