Facile synthesis of novel fluorinated thieno[2,3-d]pyrimidine derivatives containing 1,3,4-thiadiazole

一系列新奇氟化的 thieno [2,3-d ] 合并 1,3,4-thiadiazole 的嘧啶衍生物被一个灵巧的帮助微波的过程综合包括有 trifluoroacetic 酸的 2-aminothiophene-3-carbonitrile 的环合，氯化和亲核的替换反应。这个协议提供了象温和反应条件，短反应时间，简单纯化和好收益的如此的优点。产品的结构被 1H NMR， MS，元素的分析和 X 光检查衍射描绘。

A series of novel fluorinated thieno[2,3-d]pyrimidine derivatives incorporating 1,3,4-thiadiazole were synthesized by a facile microwave-assisted procedure,including the cyclization of 2-aminothiophene-3-carbonitrile with trifluoroacetic acid,chlorination and nucleophilic substitution reaction.This protocol offered such advantages as mild reaction conditions,short reaction time, simple puritication and good yields.The structures of the products were characterized by ~1H NMR,MS,elemental analysis and Xray diffraction.