赖诺普利对136例高血压病肾功能的影响

Lisinopril on 136 Cases with Hypertension the Effect of Renal Function

目的:观察探讨赖诺普利对136例高血压病肾功能的影响。方法:选择2009年2月—2011年2月高血压病患者136例为观察组,另选同期指数相近的高血压患者120例为对照组。对观察组患者进行口服赖诺普利治疗18mg/d,对照组患者接受口服缬沙坦治疗90mg/d。观察两组患者血压变化,以及24h尿蛋白、胆固醇、血肌酐、血尿素氮和不良反应的比较。结果:经4～6周治疗后,接受口服赖诺普利治疗患者总有效率为75.9%,接受口服缬沙坦治疗患者总有效率为70.6%。结论:赖诺普利可使尿蛋白含量减少,平稳有效抗压,使高血压病肾功能得到改善,临床应用安全、有效。

Objective： To explore the impact of lisinopril on renal function of 136 cases ofhypertension. Methods. This article chooses since 2009 to July 2011 02 feb, 136 cases,aged 58 years old -73 years ,with female 57 patients, male 79 cases of the observation group chose the same period 120 cases with high blood pressure similar index, age 56 years old-71 years, with female 51 cases, male 69 cases of control group. The observation group of patients with oral lisinopril 18 mg/d, patients receiving oral losartan treat ment 90 mg/d. Watch two groups were blood pressure changes, and 24 h urine protein, cholesterol, blood serum creatinine, blood urea nitrogen and adverse reaction of the comparison. Results ： After four to six weeks after the treatment, receiving oral lisinopril patients the total effective rate was 75.9 % , receiving oral losartan treat patients with the total effective rate was 70.6 %. Conclu- sion：Lisinopril can make the urine proteincontent, thesmoothandefficient compression, hypertension renalfunction improved, safe and effective.