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急性脑梗死合并代谢综合征对脂蛋白相关磷脂酶A_2的影响 被引量：2

Levels of bloodplasma Lp-PLA_2 in patients with acute cerebral infarction complicated by metabolic syndrome
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摘要 目的探讨急性脑梗死合并代谢综合征(metabolic syndrome,MS)对脂蛋白相关磷脂酶A2(lipoprotein-associ-ated phospholipase A2,Lp-PLA2)的影响。方法根据国际糖尿病联盟(IDF)MS诊断标准,将74例急性脑梗死患者分为MS组及非MS组两组。检测各组血浆高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、三酰甘油(TG)及总胆固醇(TC)水平与腰围。结果 MS组LP-PLA2水平(38.87±5.44)较非MS组(36.44±4.15)明显升高,两组比较差异有统计学意义(P=0.037)。同时伴有TG明显升高及腰围的差异。结论 MS患者Lp-PLA2水平升高,Lp-PLA2可能与MS相关。 Objective To investigate the level of blood plasma Lp - PLA2 in patients with acute cerebral infarction complicat- ed by metabolic syndrome（MS） and to investigate the correlation between LP - PLA and MS. Methods We studied 74 hospitalized patients with acute cerebral infarction. They were divided into MS group and non - MS group according to the criteria of MS published by International Diabetes Federation （IDF）. The level of blood plasma Lp - PLA2 and blood serum TC, TG, LDL - C, HDL - C was detected by ELISA. Results Significant difference was observed between patients with acute cerebral infarction complicated by MS in levels of plasma Lp - PLA2 and non - MS group （38.87 ±5.44 vs 36.44 ± 4.15, P = 0. 037 ）. The level of serum triglyceride （TG） was also higher （ P 〈 0.05 ）. Conclusions MS induces elevation of the level of plasma Lp - PLA2.
作者 朱立勋 耿瑞慧 陆学胜 丁素菊
机构地区 上海长宁区中心医院神经内科 武警 第二军医大学附属长海医院神经内科
出处 《武警医学》 CAS 2012年第5期378-380,共3页 Medical Journal of the Chinese People's Armed Police Force
关键词 脂蛋白相关磷脂酶A2 代谢综合征 急性脑梗死 lipoprotein- associated phospholipase A2 metabolic syndrome acute cerebral infarction
分类号 R743 [医药卫生—神经病学与精神病学]
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参考文献17

  • 1Davis B,Koster G,Douet L J. Electrospray ionization mass spectrometry identifies substrates and products of lipoprotein-associated phospholipase A2 in oxidized human low density lipoprotein[J].Journal of Biological Chemistry,2008,(10):6428-6437.
  • 2Grundy S M,Cleeman J I,Merz C N. Implication of recent clinical trials for the national cholesterol education program adult treatment panel III guidelines[J].Circulation,2004,(06):227-239.
  • 3Alberti K G,Zimmet P. The metabolic syndrome-a new worldwide definition[J].The Lancet,2005,(9491):1059-1062.doi:10.1016/S0140-6736(05)67402-8.
  • 4Schaloske R H,Dennis E A. The phospholipase A2 surperfamily and its group numbering system[J].Biochimica Et Biophysica Acta,2006,(11):1246-1259.
  • 5Tjoelker L W,Eberhardt C,Unger J. Plasma platelet-activating factor acetylhydrolase is a secreted phospholipase a with a catalytictriad[J].Journal of Biological Chemistry,1995,(43):25481-25487.
  • 6Tselepis A D,Dentan C,Karabina S A. PAF-degrading acetylhydrolase is preferentially associated with dense LDL and VHDL-1 in human plasma.Catalytic characteristics and relation to the monocyte-derived enzyme[J].Arteriosclerosis,Thrombosis,and Vascular Biology,1995,(10):1764-1773.
  • 7Zalewski A,Macphee C. Role of lipoprotein-associated phospholipase A2 in atherosclerosis:biology,epidemiology,and possible therapeutic target[J].Arteriosclerosis,Thrombosis,and Vascular Biology,2005,(05):923-931.
  • 8Blake G J,Dada N,Fox J C. A prospective evaluation of lipoprotein associated-phospholipaseA(2) levels and the risk of future cardiovascular events in women[J].Journal of the American College of Cardiology,2001,(05):1302-1306.doi:10.1016/S0735-1097(01)01554-6.
  • 9Brilakis E S,Khera A,McGuire D K. Influence of race and sex on lipoprotein-associated phospholipase A2 levels:observations from the Dallas Heart Study[J].Atheroclerosis,2008,(01):110-115.
  • 10Kim J A,Yeh D C,Ver M. Phosphorylation of Ser 24 in the pleckstrin homology domain of insulin receptor substrate1by Mouse Pelle-like kinase/interleukin-1receptor-associated kinase:cross-talk between inflammatory signaling and insulin signaling that may contribute to insulin resistance[J].Journal of Biological Chemistry,2005,(24):23173-23183.

同被引文献24

  • 1贾建平,陈生弟,主编.神经病学[M].7版.北京:人民卫生出版社,2013.
  • 2Brouns R, DeVil B, Cras P, et al. Neurobiochemical markers of brain damage in cerebrospinal fluid of acute ischemic stroke pa- tients[J].Clin Chem,2010,56(3) :451-458.
  • 3Streitbiirger DP, Arelin K, Kratzsch J, et al. Validating serum S]00B and neuron-specific enolase as biomarkers for the human brain-a combined serum, gene expression and MRI studyFJ~. PLoS One, 2012,7 (8) : e43284.
  • 4Costine BA, Quebeda-Clerkin PB, Dodge CP, et al. Neuron-specific enolase, but not S100B or myelin basic protein, increases in pe- ripheral blood corresponding to lesion volume after cortical impact in piglets[J].J Neurotrauma, 2012,29 (17) : 2689-2695.
  • 5Woertgen C, Rothoefl RD, Brawanski A. Neuron-specific enolase serum levels after controlled cortical impact injury in the rat[J].J Neuotrauma, 2001,18 (5) ~ 569-573.
  • 6Zaheer S,Beg M,Rizvi I,et al.Correlation between serum neuron specific enolase and functional neurological outcome in patients of acute ischemic stroke/-J~. Ann Indian Aead Neurol, 2013, 16 (4): 504 508.
  • 7Bharosay VV, Varma M, Saxena K, et al.Correlation of brain bio- marker neuron specific enolase (nse) with degree of disability and neurological worsening in cerebrovaseular stroke[J].Indian J Clin Biochem,2012,27(2) : 186 190.
  • 8Mukhtarova SN. Significance of neurospecific enolase determina- tion in estimation of severity of hypoxic~ischemic injury of new- born brain[J]. Georgian Med News, 2010,181 ( 1 ) : 49-54.
  • 9Wunderlich MT, Lins H, Skalej M, et al. Neuronspecific enolase and tau protein as neurobiochemical markers of neuronal damage are related to early clinical course and long-term outcome in acute isehemie stroke[J]. Clin Neurol Neurosurg, 2006,108 (6) : 558-563.
  • 10Oh SH, Lee JG, Na SJ, et al. The effect of initial serum neuron- specific enolase level on clinical outcome in acute carotid artery territory infarction[J].Yonsei Med J, 2002,43(3):357-362.

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武警医学
2012年 第5期

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