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胰岛素强化对新诊断2型糖尿病胰岛素抵抗的影响 被引量：4

Effect of transient intensive insulin treatment on insulin resistance in newly diagnosed type 2 diabetic patients
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摘要 目的研究新诊断2型糖尿病患者分别接受持续性皮下胰岛素输注(continuous subcutaneous insulin infusion,CSⅡ)和多次皮下注射胰岛素(multiple subcutaneous insulin injection,MSⅡ)治疗对胰岛素抵抗的影响。方法新诊断的2型糖尿病患者分别接受CSⅡ和MSⅡ治疗2周,计算胰岛素敏感指数(SIM),评价胰岛素敏感性的变化。结果治疗后CSⅡ组SIM(26.98±11.99)较MSII组SIM(22.14±9.00)明显升高,两组比较差异有统计学意义(P=0.042)。结论新诊断的2型糖尿病患者短期应用胰岛素泵强化治疗可增加胰岛素的敏感性。 Objective To evaluate the variance of insulin resistance after continuous subcutaneous insulin infusion （ CSⅡ ） or multiple subcutaneous injection （ MSⅡ ） therapy in newly diagnosed type 2 diabetic patients. Methods Sixty newly diagnosed type 2 diabetic patients were randomly divided into two groups ： CS Ⅱ and MS Ⅱgroup. SIM were calculated to evaluate the variance of insulin sensitivity. Results SIM（26.98 ± 11.99）were significantly higher in CSⅡ group than （22.14 ±9.00）in MS Ⅱgroup, P =0.042. Conclusions Short - term CS Ⅱ can effectively increase insulin sensitivity in newly diagnosed type 2 diabetic patients.
作者 武晋晓 许秀萍 焦秀敏 张星光 陈彬 吕肖锋
机构地区 北京军区总医院内分泌科
出处 《武警医学》 CAS 2012年第5期383-385,共3页 Medical Journal of the Chinese People's Armed Police Force
基金 军队十一五课题(06MA067)
关键词 2型糖尿病 胰岛素泵 胰岛素抵抗 type 2 diabetes insulin pump insulin resistance
分类号 R587.1 [医药卫生—内分泌]
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参考文献7

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二级参考文献10

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共引文献776

同被引文献45

  • 1徐成斌.糖尿病血脂异常治疗进展(下)[J].中国医刊,2004,39(10):2-4. 被引量：8
  • 2邹大进.超重和肥胖——代谢综合征的主要病因[J].国外医学（内分泌学分册）,2005,25(3):145-147. 被引量：56
  • 3梅青.罗格列酮治疗早期糖尿病肾病临床效果观察[J].中国医药,2006,1(12):732-733. 被引量：8
  • 4UK Prospective Diabetes Study (UKPDS) Group.Intensive blood glucose control withsulphonylureas or insulin compared with conventionaltrealment and risk ofcompfication in patient with type 2 diabetes[J]. Lancet, 1998, 352(9131) : 837-853.
  • 5Diabetes control and complication trail research (DCCT). The effect of intensive treatment of diabetes on the development and progression of long time complication in insulin dependent diabetes[J]. N EngIMed, 1993, 329(14):977-986.
  • 6Yang W, Liu J, Weng Let al. prevalence of diabetes among men and women in china[J]. N Engl J Med, 2010, 13(12): 40-55.
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  • 8中华医学会糖尿病学分会.中国2型糖尿病防治指南(2010年版)[S].中国糖尿病杂志,2012,20(1):S6.
  • 9谭格铭.浅释中医糖尿病"三多一少"症和糖尿病并发症以及对之治疗的见解[J].中外健康文摘,2013,10(12):56-57.
  • 10黄秋霞,孙庆凯,杜巍,刘玉华,张秀薇,陈丹,孙晓玲,莫桂英.胰岛素泵治疗对初诊2型糖尿病患者胰岛细胞功能的影响[J].广东医学,2008,29(2):175-176. 被引量：5

引证文献4

二级引证文献17

武警医学
2012年 第5期

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