新生儿坏死性小肠结肠炎发病机制及防治研究进展

Advances in the pathogenesis, prevention and treatment in necrotizing enterocolitis of newborn

新生儿坏死性小肠结肠炎（necrotizing enterocolitis of newborn，NEC）在新生儿期发病率及致死率均较高，其发病的病理生理学机制尚未完全阐明，治疗上主要限于对症支持治疗。近年来，较多研究发现大量炎症因子及其介导的信号途径在NEC发生发展过程中具有重要作用；另外，在蛋白质组学、肠道微生态等领域的研究也取得了一些进展。在NEC的防治上，提倡早期母乳喂养和应用微生态制剂。本文就上述领域的研究作一综述，为探讨NEC发病机制及防治奠定基础。

Necrotizing enterocolitis of newborn （NEC） remains a significant cause of morbidity and mortality in neonatal intensive care units. Although many advances have been made in the understanding of this disease, the pathophysiology remains incompletely clear, and treatment is mainly limited to supportive care. In recent years, studies have focused on the role of the inflammatory mediators, signaling and their im- pacts on the disease process. Investigators also made some advances in the fields of intestinal proteome and probiotics. Early breastfeeding and probiotics are promoted to prevent and/or ameliorate neonatal NEC. In this artical, we reviewed the advances in the above fields for helping to the pathogenesis and treatment of NEC.