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低剂量辐射对荷瘤小鼠肝脏抗氧化酶的影响及肿瘤组织的病理改变 被引量:1

The change of the pathology and anti-oxidase in the tumor-bearing mice liver with low dose irradiation.
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摘要 低剂量全身照射及合并肿瘤组织局部大剂量照射表明 ,低剂量辐射可以诱导肝脏抗氧化酶升高 ;预先给予 0 0 5Gy全身照射 ,6小时后在施以大剂量X射线肿瘤局部照射较单纯施用大剂量照射者肝细胞过氧化脂质 (LPO)含量降低 ,谷胱甘肽过氧化物酶 (GSH -Px)、超氧化物歧化酶 (SOD)活性增强。肿瘤组织病理研究表明 ,应用低剂量辐射 ,肿瘤组织内见明显的毛细血管增生 ,浸润淋巴细胞 (TIL)数增加。研究表明 ,大剂量肿瘤组织照射前采用低剂量全身照射对机体正常组织有保护作用 ,同时也有利于对肿瘤组织的杀伤作用。 Objective: To understand the change of tumor-bearing mice malignant tissue pathology and liver antioxidase.Method:Using enzymological and pathological analysis to study the active of SOD、GSH-Px,content of LPO in liver as well as the change of carcinoma tissue.Results:The study shown that the active of antioxidose in liver were aroused for the tummor-bearing mice whosewhole bady pre-exposed to 50 mGg low dose X-ray.The level of MDA was reduced.In the condition of large dose X-ray local irradiation radiotherapy increased gradually after low dose irradiation,the active of the SOD and GSH-Px showed a tendency of increase more than that of contrast groups.At that time the content of the MDA reached that of contrast group.Under optical microscope many lgmphocytes were found to be invoded by the neighbovring malignant tissnes,capillaries,to be dilated and hyperemia occurred.Conclusion:Low dose irradiation can stimulate the active of antioxi dase system in liver of tumor-bearing mice and enhance it to high;Under the condition of large dose radiotherapy SOD、GSH-Px can be induced by the pre-exposed 50mGy low dose irradiation,on the contrary,LPO be reduced;Low dose irradiation can promote the effect of radiotherapy and play a role as radioprotect effect on the normal physiological function.
出处 《中国辐射卫生》 2000年第1期6-7,共2页 Chinese Journal of Radiological Health
关键词 低剂量辐射 荷瘤小鼠 抗氧化酶 肿瘤 Low dose irradiation antioxidase tumor-bearing mice
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  • 1陈顺志,金有余,李常淳,张增权.过氧化脂质TBA显色的三种方法学比较[J]临床检验杂志,1984(04).

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