南昌市2009年麻疹减毒活疫苗强化免疫活动效果分析

Analysis on effectiveness of measles attenuated live vaccine supplementary immunization activities in Nanchang at 2009

目的评价2009年南昌市麻疹减毒活疫苗(Measles Attenuated Live Vaccine,MV)强化免疫活动(Supplemen-tary Immunization Activities,SIA)效果,为消除麻疹提供依据。方法对南昌市2009年10月麻疹疫苗强化免疫期间的摸底调查、现场接种、评估报告等资料和强化免疫前后的中国疾病预防控制信息系统中麻疹疫情资料进行综合分析。结果该次强化免疫共接种目标儿童988 959剂次,报告接种率为97.91%(988 959/1 010 096),快速评估调查接种率为96.94%(1 745/1 800);MV SIA后人群麻疹抗体阳性率、保护率分别为91.99%、70.83%,抗体GMT从免疫前的1∶555上升到免疫后的1∶1 625.28,免疫前后人群麻疹抗体GMT差异有统计学意义(t=4.795,P=0.000)。本次强化免疫共报告疑似预防接种异常反应(Adverse Events Following Immunization,AEFI)25例,发生率为2.53/10万;强化免疫后的2009年11月～2010年10月全市报告麻疹病例10例,发病率为0.20/10万,较2008年11月～2009年10月同期病例明显减少。结论高质量的MV SIA能迅速提高人群的抗体水平,降低麻疹发病率,适时开展MV SIA是加速麻疹控制最安全有效的措施之一。

Objective To evaluate the effectiveness of measles attenuated live vaccine（MV）supplementary immunization activities（SIA）in Nanchang in 2009 and provide basis for elimination measles.Method Collecting the data of basic investigation,scene vaccination and evaluation reports during measles vaccine supplementary immunization time of October 2009,all them comprehensive analysis with the data before and after supplementary immunization which collected from China Disease Prevention and Control Information System.Results This supplementary immunization had inoculation goal children 988 959 times,the reporting inoculation rate was 97.91%（988 959/1 010 096）,the rapid assessment survey inoculation rate was 96.94%（1 745/1 800）.MV SIA measles antibody positive rate,protection rate were 91.99%,70.51%,respectively.GMT antibody was raised from 1∶ 555 preimmune up to 1∶ 1625.28 after immunization,there was significant difference between the two（t=4.795,P=0.000）.Total of 25 cases of adverse events following immunization（AEFI） were reported,the incidence rate was 2.53/10 million.10 measles cases were reported during November of 2009 to October of 2010 after supplementary immunization,the incidence rate was 0.20/10 million,the cases were lower than the same period of 2008 to 2009.Conclusions Quality MV SIA can rapidly improve the measles antibody level,lower incidence rate.Carrying out MV SIA was one of the safe and effective measures to accelerate measles control.