肺癌患者HP感染与胃泌素水平变化的临床意义

Clinical significance of relationship between Hp infection and Gastrin level in patients with pulmonary cancer

目的观察肺癌患者HP感染状况与胃泌素水平变化,探讨肺癌患者HP感染与胃泌素水平变化与肺癌发生的关系。方法采用14C呼气试验和放射免疫法对34例肺癌患者和42例支气管炎患者、29例支气管扩张患者进行HP感染检测和胃泌素水平测定。结果肺癌组幽门螺旋杆菌感染率与支气管炎患者、支气管扩张患者差异无统计学意义;肺癌组胃泌素水平明显高于支气管炎和支气管扩张组。结论部分肺癌患者存在HP感染和高胃泌素血症,但HP感染可能不是引起高胃泌素血症的主要因素。

Objective To observe HP infection status and gastrin level in the patients with lung cancer,explore the relationship between lung cancer and HP infection and gastrin level.Method Testing the Hp infection status and gastrin level of 34 patients with lung cancer,42 with chronic bronchitis,29 with bronchiectasis by 14C breath test and RI method.Results The HP infection rate in lung cancer had no difference with that in chronic bronchitis group and bronchiectasis group,but gastrin level was significantly higher than other groups.（P〈0.01）.Conclusions There were hypergastrinemia and HP infection in part of lung cancer patients,HP infection was not the main reasons lead to hypergastrinemia.