摘要
用钙拮抗剂山莨菪碱对感染抗氯喹伯氏疟原虫小鼠进行辅助治疗,高、中、低三个剂量均可明显抑制原虫生长,使小鼠存活时间延长,但剂量为5mg/kg.d或40mg/kg.d时辅助治疗作用明显低于剂量为20mg/kg.d时(此剂量时实验组d_4的平均原虫率为46.41‰,对照组67. 6‰。X^2=46.34,P<0.005;实验组小鼠死亡时间几何均数为13.64±0.99d.对照组为9.18±0.80d,t=3.001,P<0.05)。山莨菪碱逆转伯氏疟原虫氯喹抗药性的作用存在一个最适剂量。
As an auxiliary treatment, anisodamine. a calcium antagonist, was used to treat mice infected by chloroqume resistant Plasmodium berghei. An obvious reverse effect of the drug on chloroqume resistance was observed. The growth of parasitemia in these mice was inhibited obviously by different doses of anisodamine and the mean survival time of these mice was longer than that of the controls (P<0. 05). It was found that the effect of dose at 20 mg/kg.d was higher than that of dose at 5 mg/kg.d or 40 mg/kg.d and the difference was very significant (P<0. 005). It is considered that anisodamine can reverse chloroquine resistant of Plasmodium berghei and has an optimum reversal dose.
出处
《西南国防医药》
CAS
2000年第2期65-67,共3页
Medical Journal of National Defending Forces in Southwest China
关键词
山莨菪碱
钙拮抗剂
伯氏疟原虫
抗药性
anisodamine calcium antagonist Plasmodium berghei drug resistance
