摘要
为探讨大鼠阴茎组织中一氧化氮合酶 (NitricOxideSynthase,NOS)分布及增龄对其的影响。本文采用NADPHd组化对不同月龄大鼠 (2、8、16、2 4月 )阴茎组织进行染色。结果显示NOS主要分布于大鼠阴茎组织平滑肌细胞 ,而内皮细胞和神经纤维含量较少 ;随年龄增加 ,阴茎组织中NOS表达逐渐减弱 ,各月龄组间差别明显。结论认为大鼠阴茎组织中NOS主要存在于平滑肌细胞 ,增龄使NOS明显减少 ,表明NOS减少可能与勃起障碍的年龄依赖性相关。
In order to explore the distribution of nitric oxide synthase (NOS) in rat penile tissue and effect of aging on NOS.NOS was detected in penile tissue of rats of four age(2,8,16,24 months)using nicotinamide adenine dinucleatide phosphate (NADPH) diaphorase staining.The results showed that the presence of NOS was mainly seen in smooth muscle cell while less in endothelial cell and nerve fibers.Positive staining for NOS decreased significantly with aging.It implys the decrease of NOS in probably relate to age dependent feature of erectile dysfunction.
出处
《中国男科学杂志》
CAS
CSCD
2000年第1期9-12,共4页
Chinese Journal of Andrology
关键词
大鼠
阴茎组织
年龄
勃起障碍
一氧化氮合酶
erectile dysfunction (ED)
nitric oxide synthase (NOS)
NADPH diaphorase
aging
