血管生成素-2与肿瘤血管生成的研究进展

Angiopoietin-2 and tumor angiogenesis

肿瘤血管生成是恶性肿瘤快速增殖和转移的重要途径，多种细胞及分子因素参与肿瘤血管生成过程。血管生成素-2（Ang-2）是重要的血管内皮生长因子之一，主要通过松解血管结构、破坏血管稳定性而影响肿瘤血管生成。近年来研究证实Ang-2在肿瘤血管生成中与其他血管生长因子相互作用共同调节新生血管形成。随着研究的新进展，Ang-2不仅会成为抗肿瘤血管生成治疗的重要靶点，而且联合其他信号通路作为共同靶点将进一步提高临床抗肿瘤疗效。

Tumor angiogenesis is an important way of rapid proliferation and metastasis for malignancies, and a variety of cellular and molecular factors involved in the process. Angiopoietin-2 （ Ang-2 ） is one of the important vascular endothelial growth factor, which influences tumor angiogenesis mainly through releasing vascular structures and damaging the vessel stability. Recent researches reveal that Ang-2 modulates tumor angiogenesis interacting with other vascular growth factors. With the new research progress, Ang-2 will not only be an important target for antiangiogenic therapy, but also further improve clinical efficacy of antitumor therapy combined with other signal pathways as common targets.