肝细胞生长因子及其受体在多发性骨髓瘤中的研究进展

Hepatocyte growth factor and its receptor in multiple myeloma

肝细胞生长因子（HGF）是一个多功能的细胞因子，作用于细胞表面的跨膜受体c—Met发挥生物学作用。许多肿瘤的生长、侵袭和转移都与HGF-c-Met信号转导通路异常有关。HGF及其受体c-Met与多发性骨髓瘤（MM）的发生、转移、侵袭及预后关系密切。

Hepatocyte growth factor （ HGF）, a muhifunctional cytokine, plays a biological role through acting on the cell surface transmembrane receptor c-Mct. The growth, invasion and metastasis of many tumors are associated with the abnormalities of HGF-c-Met signaling pathway. Studies found that HGF and its rcccptor c-Met have close relations with the occurrence, metastasis, invasion and prognosis of multiple myeloma.