老年前期及老年性白内障患者的全血半乳糖激酶活性研究

Studies on Blood Galactokinase of Patients with Presenile and Senile Cataracts

本文测定了60例老年前期白内障和77例老年性白内障患者的全血半乳糖激酶(GK)活性。此二组的GK活性水平均与对照组一致(P>0.05),但老年前期白内障组中GK杂合子频率显著高于对照组,提示GK活性部分降低者发生白内障的危险也比正常人大。因此,不论是GK缺乏的纯合子还是杂合子,均应限制乳品的摄取。

Whole blood galactokinase (GK) activities were determined in 278 individuals including 77 patients with senile cataracts, 60 with presenile cataracts and 141 normal controls. No significant difference was found among the GK levels of the three groups. The frequency of GK heterozygocity in the presenile cataract group, however, was significantly higher than that in the normal control group (P<0.0l), suggesting that even a partial decrease in GK activity might facilitate cataract formation in relatively early stages of life. The intake of milk and its products should be limited, both in GK homo-and heterozygotes.