两种不同剂量吉非罗齐对原发性高脂血症的临床疗效比较

A Clinical Study on Efficacy of Two Different Dosages Gemfibrozil Administered in Hyperlipidemic Patients

为探讨去非罗齐用药剂量与临床疗效之间的关系 ,将 12 1例原发性高脂血症患者随机分为低剂量组和常规剂量组 ,低剂量组患者用吉非罗齐 6 0 0mg/d治疗 ,常规剂量组患者用吉非罗齐 12 0 0mg/d治疗 ,观察两组患者服药前及服药 4周、8周血脂水平的变化。结果发现 ,服药 4周常规剂量组血清总胆固醇和甘油三酯下降 ,高密度脂蛋白胆固醇上升 ,与治疗前有非常显著性差异 (P <0 .0 1) ,而低剂量组仅甘油三酯下降 (P <0 .0 5 )。服药 8周常规剂量组和低剂量组血清总胆固醇和甘油三酯下降 ,高密度脂蛋白胆固醇上升 ,与治疗前相比差异均有非常显著性统计学意义 (P <0 .0 1)。此结果提示 ,用低剂量吉非罗齐治疗原发性高脂血症患者虽然强度偏弱 ,但副作用少 ,值得提倡。

Aim [WT5”BZ]The present study was to compare the clinical efficacy of low dose gemfibrozil with normal dose gemfibrozil administered in hyperlipidemic patients. [WT5”HZ]Methods [WT5”BZ]121 subjects were randomized into two groups: 62 Subjects in low dose gemfribrozil group,59 subjects in normal dose gemfibrozil group as controls. Blood lipid levels were determined prior to lipid lowering treatment and at the end of 4th and 8th week treatment respectively. [WT5”HZ]Results [WT5”BZ] At the end of the 4th week treatment, levels of TC and TG in normal dose gemfibrozil group significantly reduced (P<0.01), and levels of HDLC in normal dose group obviously increased (P<0.01), only levels of TG in low dose group reduced (P<0.05), after treatment compared with the prior to treatmant. At the end of the 8th week treatment, levels of TC and TG significantly reduced and levels of HDLC obviousely increased in both groups. Both of difference were statistically significant (P<0.01). [WT5”HZ]Conclusion [WT5”BZ] Not only was the efficacy of low dose group significantly weaker than that of normal dose group but also the side effects of low dose group was lower