我国蒙古族人群血浆载脂蛋白E的表型分布及其等位基因频率

Distribution of ApoE Phenotypes and Frequencies of ApoE Alleles in Mongolian Population

Zannis等通过对许多家族成员的研究发现,载脂蛋白E(apoE)的异构蛋白质受一遗传位点上3个等位基因(ε2、ε3和ε4)所控制,而3个等位基因又决定着人群中6个遗传表型的出现频率.apoE表型分布和等位基因频率的研究在西方国家已有报道,在日本和我国汉族人群的研究结果也已报道.东、西方民族心血管病发病率存在明显差异,而东方民族人群中apoE3/3表型的出现频率明显高于西方民族.我国是一个多民族国家,各族人民的生活习惯、饮食成分及心血管发病率均存在一定差异.为进一步了解人血浆apoE表型分布和其等位基因频率的种族差异,本实验对蒙古族人群apoE表型分布和等位基因频率进行研究.并将其与我国汉族和西方人群的研究结果进行比较.

Distribution of apoE3/3, E3/4 and E2/3 were 88.2%, 9.7% and 2.2%, respectively, in a Mongolian population. No apoE2/2,E2/4 or E4/4 phenotypes were found in this study. The population of apo E3/3 and frequency of e3 in this Mongolian population were significantly higher than those of Western populations and the Han nationality of China.The above results indicated that apoE phenotypes are closely related to lipid levels. The cholesterol levels of individuals with apoE3/3 phenotype were much lower than those of individuals with apoE2/3 (P<0.01) and higher than those of individuals with apoE3/4 (P<0.05). The levels of apoA-1 of individuals with apoE3/3 were much lower than those of individuals with apoE2/3 (P<0.01), but no difference was found between apoE3/3 and apoE3/4 phenotypes (P>0.05).