Sjamp对纤溶系统影响的初步观察

Preliminary Observations on the Effect of Sjamp on the Fibrinolytic System

本实验研究刺参酸性粘多糖(Sjamp)对纤维蛋白溶解活性的影响,结果表明Sjamp在体外可使纤维蛋白溶解,其作用强于肝素,但对不含纤溶酶原的凝块则促纤溶作用消失,提示Sjamp可能通过激活纤溶酶原而使纤维蛋白溶解。体内试验亦表明,给兔静脉注射Sjamp后,兔血浆纤溶活性增高,FDP浓度也增加。Sjamp抑制纤维蛋白单体聚合作用从而进一步影响纤维蛋白凝块的结构,可能是其促纤溶活性高于肝素的原因之一。

The effects of Sjamp, an acidic mucopolysaccharide extracted from Sticho-pus japonicus Selenka, on fibrinolytic activities were studied. The results showed that Sjamp could induce fibrinolysis in vitro, and the effects were stronger than those of heparin. The fibrinolytic activity of Sjamp disappeared when plasminogen was removed from the fibrin clot. This suggested that the fibrinolytic activity of Sjamp might depend upon plasminogen activation. The fibri- nolytic activity and FDP concentration of rabbit plasma increased after intravenous injection of Sjamp. Fibrin monomer polymerization (FMP) was also inhibited by Sjamp, so the structure of fibrin clots might be altered, facilitating lysis. The mechanism of fibrinolytic effect of Sjamp and the significance of this effect in biomedicine are discussed.