肢端肥大症患者垂体生长激素细胞对多巴胺能药物反应异常的研究

Studies on the Abnormal Response of Pituitary Somatotroph to Dopaminergic Drugs in Patients with Acromegaly

为研究多巴胺(DA)能药物对垂体生长激素(GH)细胞功能的影响.静脉滴注(iv gtt)DA及口服左旋多巴(LD),结果正常人及肢端肥大症患者的GH分泌分别受到兴奋和抑制,而联合服用LD及卡比多巴(CD),则LD抑制肢端肥大症患者GH分泌的作用消失,支持垂体GH细胞异常是其对DA能药物反应异常的原因。

This article studies the effects of dopaminergic drugs on the pituitary GH secreting adenoma. The secretion of GH was enhanced and suppressed in 6 normal adults and 5 acromegalic patients respectively after intravenous infusion of dopamine and oral ingestion of L-dopa. Simultaneous administration of L-dopa and carbidopa (a drug that inhibits the. conversion of L-dopa to dopamine in peripheral tissue) showed no suppressive or stimulatory effect on the secretion of GH in acromegaly. This result indicates that an abnormality in the GH secreting cell may be the cause of the different responses of GH to dopaminergic drugs in acromegaly.