行气破血法治疗重度黄疸型肝炎的降黄作用及对预后的影响

Jaundice falling and influence to prognosis of Xingqi Poxue(行气破血) treating severe icterohepatitis

目的 :观察行气破血法治疗重度黄疸型肝炎的降黄效果及对预后的影响。方法 :12 4例患者随机分为2组 ,治疗组 6 0例 ,对照组 6 4例 ,2组均采用基础治疗和促肝细胞生长素。治疗组加用行气破血中药治疗。观察比较 2组总胆红素 (Tbil)、直接胆红素 (Dbil)的变化 ,及黄疸持续时间以判定降黄疗效。结果 :治疗组治疗前直接胆红素∶总胆红素 (D∶ T) <6 0 % ,尿胆红素阴性 ;治疗后 D∶ T比值、凝血酶原活动度及尿胆红素均明显上升 ,黄疸下降 ;黄疸持续时间较对照组平均缩短 13.77日 (P<0 .0 5 ) ;治疗组降黄总有效率为 86 .7% ,显著高于对照组 37.5 % (P<0 .0 5 )。治疗组病死率为 2 5 .0 % ,明显低于对照组 33.3%。结论 :行气破血疗法降黄效果显著 ,黄疸持续时间缩短 ,对重度黄疸型肝炎患者预后较好。

Objective:To observe the clinical effect of jaundice falling and influence to prognosis of Xingqi Poxue(行气破血) on severe icterohepatits.Methods:124 cases were randomly divided into two groups,60 cases in the treatment group and 64 cases in the control group.Under the same basic therapy and large doses of hepatocyte growthpromoting factors (HGF) in both two groups,the method of Xingqi Poxue was added in the treatment group.The ratio of direct bilirubin to total bilirubin (D/T),durative time of jaundice were observed.Results:Before treatment the ratio of D/T was 60% in the treatment group,urine bilirubin was negative,while after treatment the ratio of D/T,activity of thrombinogen and urine bilirubin were all rised and jaundice was fallen.Duration of jaundice was averagely 13 77 days less than that in the control group ( P <0 05).Total significant rate of jaundice fallen was 86 7% in the treatment group,which was obviously higher than that in the control group (37 5%),P<0 05.Mortality rate in the treatment group was 25 0%,while in the control group was 33 3%.Conclusions:The method of Xingqi Poxue can reduce jaundice efficiently,shorten the duration of jaundice and provide well prognosis to severe icterohepatitis.