黄芪注射液对急性心肌梗死静脉溶栓治疗再灌注损伤的影响

Influences of astragulas injection on reperfusion injury of intravenous thrombolytic therapy in patients with acute myocardial infarction

目的 :探讨黄芪注射液对急性心肌梗死 (AMI)静脉溶栓治疗后再通及并发症的影响。方法 :82例AMI患者随机分为黄芪组 (38例 )和对照组 (44例 )。2组均以尿激酶 (10 0～ 15 0 )× 10 4U常规溶栓治疗 ,黄芪组在溶栓治疗的同时静滴黄芪注射液 6 0 ml加入 5 %葡萄糖 (或生理盐水 ) 2 5 0 ml,每日 1次 ,连用 10日后比较 2组再通标准各项指标及并发症情况。结果 :2组再通标准指标中 ,再灌注性心律失常发生率黄芪组为 5 5 .5 6 % ,明显低于对照组 82 .86 % ,2组有显著性差异 (P<0 .0 5 ) ;心力衰竭及梗死后心绞痛发生率 (7.89%和 2 .6 3% )均明显低于对照组 (31.82 %和 2 0 .45 % ) ,P均 <0 .0 5 ;休克及总病死率也均低于对照组。结论 :黄芪注射液配合尿激酶溶栓治疗 AMI,可提高疗效 ,减少再灌注性心律失常等并发症和降低病死率。

Objective:To investigate the effect of astragulas injection in the intravenous thrombolytic therapy of acute myocardial infarction (AMI).Methods:82 AMI patients were divided into two groups (n 1=38,n 2=44) and were given the routine treatment of urokinase (100150)×10 4 U.In group 1,astragulas injection 60 ml was used additionally for 10 days,then the recanalization index and the incidence of complications were compared.Results:The incidence of reperfusion arrhythmia was 55 56% in group 1 and 82 86% in group 2,which was significant (P<0 05).The morbidity of cardiac failure and angina pectoris was decreased in group 1 (all P<0 05).The incidence of shock and total mortality in group 1 were also decreased.Conclusions:Astragulas injection is able to enhance the effect of thrombolytic therapy in AMI patients and decrease both the incidence of complications and total mortality.