极化液联用葛根素治疗急性心肌梗死对QT离散度的影响

Influences on QT dispersion for acute myocardial infarction combine with puerarin and western medicine

目的 :探讨葛根素联用极化液对急性心肌梗死 (AMI)患者治疗前后 QT离散度 (QTd)、校正 QT间期离散度 (QTcd)的影响 ,以及严重室性心律失常的发生率。方法 :采用随机单盲方法 ,将 5 5例 AMI患者分为治疗组和对照组 ,测定 2组患者用药前后的 QTd和 QTcd,及严重室性心律失常的发生率。结果 :2组治疗前后QTd和 QTcd均显著降低 (P均 <0 .0 1)。治疗组严重室性心律失常的发生率为 10 .3% (3/2 9) ,显著低于对照组 34 .6 % (9/2 6 ,P<0 .0 5 )。结论 :葛根素与极化液联用能降低 AMI患者 QTd和严重室性心律失常的发生率。

Objective:To explore the effects of puerarin combine with polarizing liquor,isosorbide dinitrate and magnesium sulfate and control group of western medicine on variation of QT dispersion (QTd) and QTc dispersion (QTcd) in the patients with acute myocardial infarction (AMI),and the effects on the incidence of serious vertricular arrhythmias.Methods:A random,singleblind and respective study was performed in the two groups,the QTd and QTcd before and after treatment were determined.Results:① The QTd and QTcd of both groups were significantly decreased (all P<0 01).②The incidence of serious ventricular arrhythmias of treatment group (10 3%,3/29) was significantly lower than that of control group (34 6%,9/26),P<0 05.Conclusions:Combine with puerarin and western medicine may be decrease QTd and the incidence of serious ventricular arrhythmias in the patients with AMI.