人胚胎组织雌激素受体状况

Estrogen Receptor Content in Human Embryo

通过人胚胎雌激素受体(ER)测定发现,多数人胚器官均有ER分布,包括子宫、肝和少数脾、胃、肺。随胚龄增大而ER增加的靶器官有子宫、卵巢、睾丸及一些非靶器官,如胃、上消化道系统;随胎龄增大而递减的有下消化道。肺、心、脑和淋巴组织则呈持续低水平。 早胚ER阳性细胞(A、B、C型)计数高于胚胎后期。A、B型细胞至5月时降至低谷,6个月时又增高。在非靶器官中,C、D型细胞在4个月时为最低点,而D细胞在子宫、睾丸、和肝中很快又高。提示ER在人胚发育和分化过程中有一定意义。

Estrogen receptor (ER) content was measured in 27 human embryos , aged 3 to 7 months,with 17 - fluoreceinated estrone (17 - FE). ER was demonstrated in a uneven distribution pattern in most human embryonic organs . Most embryonic uteri and livers and a few lungs , stomaches and spleens were ER positive.The ER gradually increased with embryonic deveiopment in target organs such as the uterus , ovary and testes , as well as in some non-target areas such as mouth and upper digestive system . The ER decreased with embryonic development in the lower digestive system and were maintained at a low level in the lung , heart , brain and lymphoid organs . In the early embryo (3 to 4 months ) the ER positive cells (A , B and C type ) accounted for a greater proportion of embryonic cells than they did in the late embryonic period (5 to 7 months ). The A and B type cell counts fell to the lowest point in the fifth month and increased again in the sixth month . The C and D type cells reached the lowest point in the fourth month in non-target organs but the D type cells then dramatically increased in the uterus , testes and liver. It was suggested that ER play an important role in human embryonic development and differentiation . The ER may influence proliferative ablity of early embryonic organs and the late hormone-specific ofrgan growth .