白芍总苷联合免疫抑制剂治疗类风湿关节炎对肝功能的影响

Effect of combination of total glucosides of paeonia and immunosuppressive on transaminase in treatment of rheumatoid arthritis

目的研究白芍总苷联合来氟米特与甲氨蝶呤治疗类风湿关节炎(RA)对肝功能的影响。方法将70例诊断明确的RA患者随机分为治疗组和对照组,完成本次试验的有64例。治疗组33例给予白芍总苷+来氟米特+甲氨蝶呤;对照组31例给予来氟米特+甲氨蝶呤。治疗16周观察患者关节症状改善程度及药物副作用。结果治疗16周进行疗效比较,2组差异无统计学意义(P>0.05)。治疗组肝损害发生率低于对照组,差异有统计学意义(P<0.01)。结论白芍总苷联合来氟米特与甲氨蝶呤治疗类风湿关节炎疗效好,不良反应发生率低,尤其对肝功能影响小。

Objective To investigate the effect of different combination of total glucosides of paeonia and Leflunomide and methotrexate on transaminase in the treatment of rheumatoid arthritis.Methods 70 patients were divided into 2 groups randomly,Only 64 patients completed in this experiment.33cases of treatment group were given total glucosides of paeonia and Leflunomide and 31 cases of control group were given Leflunomide and methotrexate.We measured the improve degree of joint symptoms and drug side effect ifour months later.Results There was no different in the effect of the treatment group and the control group（P〉0.05）.The rate of hepatic injury in treatment group was lower than that of group control and the differences was significant（P〈0.01）.Conclusion It is more effective in the treatment of active RA with combining TGP with little side effect to liver function.