铁路女职工高血压、高血糖、高脂血症与子宫肌瘤风险关联性研究

Association of hypertension,hyperglycemia,hyperlipemia with the risk of uterine leiomyomata for female staffs in railway system

目的了解子宫肌瘤的患病风险与高血压、高血糖和高脂血症之间的关系。方法采用横断面研究方法,由体检医师于2008年对济南地区铁路系统6164名已婚在职女职工进行健康检查,妇科检查内容包括B超检查和妇科常规检查,并进行血压和空腹血糖、甘油三酯、胆固醇等指标的测定。同时以问卷方式收集研究对象的基本信息和疾病史等情况。按照研究对象是否患有子宫肌瘤分为两组,采用Logistic回归分析方法在控制其他影响因素条件下分析子宫肌瘤与高血压、高血糖、高脂血症之间的关联性。结果研究对象子宫肌瘤患病率为20.93%,平均年龄(40.07±8.20)岁;高血压、高血糖和高脂血症患病率分别为8.20%、3.09%和10.68%。高血压是子宫肌瘤的独立危险因素(OR=1.316,95%CI 1.064～1.627),舒张压每升高10mmHg子宫肌瘤患病风险增加17.1%(OR=1.171,95%CI 1.045～1.312)。结论高血压是子宫肌瘤独立的危险因素,并且子宫肌瘤患病风险随着舒张压水平的升高而增加。

Objective To understand the association of uterine fibroids risk with hypertension, hyperglycemia and hyperlipemia, and provide guidelines for the prevention of uterine leiomyomata. Methods A cross-sectional study was conducted in 2008 and 6164 married female staffs in Ji＇nan railway system were examined. Gynecological examinations including type B ultrasonic examination and gynecological conventional check, blood pressure and fasting blood sugar, triglycerides and cholesterol were measured. The basic information and medical history of subjects were collected. The subjects were divided into groups with or without uterine fibroids. Logistic regression was used to estimate the odds ratio for the association of uterine fibroids with hypertension, hyperglycemia and hperlipidemia. Results The prevalence of uterine fibroids was 20.93% , the average age was （40. 07 ＋ 8.20） years. The prevalence of hypertension,hyperglycemia and hyperlipemia was 8.20% , 1.82% and 10. 68% respectively in this population. Hypertension was significantly associated with uterine fibroids （OR = 1. 316, 95% CI1. 064 - 1. 627）. The risk of fibroids increased 17. 1% for every 10mmHg increment of diastolic blood pressure （ OR = 1. 171, 95% CI 1. 045 - 1. 312）. Conclusion Hypertension was an independent risk factor for uterine fibroids and the risk of fibroids increased with the rise of diastolic blood pressure level.