虫草胶囊联合依那普利治疗早期糖尿病肾病

Effects of Cordyceps Sinensis Mycelium Combined with Enalapril on Proteinuria in Patients with Early Diabetic Nephropathy

目的:观察虫草胶囊联合依那普利对早期糖尿病肾病患者尿蛋白排泄水平的影响。方法:68例2型早期糖尿病肾病患者,随机分为对照组34例(依那普利)和治疗组34例(依那普利联合虫草胶囊)。疗程均为12周。观察UAER,24 h尿蛋白定量,尿α1-MG、尿β2-MG水平的变化。结果:对照组治疗后UAER、24 h尿蛋白定量、尿α1-MG、尿β2-MG分别为(167.4±19.2)mg.d-1,(89.1±15.0)mg,(19.1±8.1)mg.L-1,(331.5±36.5)μg.L-1,均较治疗前降低,差异有显著性(P<0.05),治疗组分别为(115.2±16.3)mg.d-1,(58.9±18.6)mg,(15.2±7.9)mg.L-1,(272.3±33.8)μg.L-1,也较治疗前降低,较对照组降低更明显,差异有显著性(P<0.05)。两组治疗后HbA1c较治疗前略有下降,但差异无显著性。结论:虫草胶囊联合依那普利能明显降低早期糖尿病肾病患者尿蛋白水平,使肾脏损伤程度减低,较单用依那普利作用明显。

Objective： To observe the effects of cordyceps sinensis mycelium combined with enalapril on proteinuria in patients with early diabetic nephropathy. Method： Sixty-eight patients with early diabetic nephropathy were randomly divided into control group treated with enalapriland treatment grouptreated with enalapril and Ccordyceps Sinensis Mycelium, each group was treated for 12 weeks. The urinary albumin ejection rate （UAER）, 24-hour urine protein, urine a1-microglobin （a1-MG）, β2-microglobin （β2-MG） and glycosylated hemoglobin （HbAlc） were measured before and after the treatment. Result： After treatment UAER, 24-hour urine protein, a1-MG, β2-MG in both groups were significantly decreased compared with that before treatment.（P 〈 0.05 ） and the difference in combination group was significantly greater than that in single medication group （P 〈 0.05）. The difference of HbAlc before and after treatment had no statistical significance in both groups. Conclusion： The treatment with both cordyceps sinensis myceliam and enalapril can decrease proteinuria of Patients with early diabetic nephropathy markedly, and is better than the treatment with enalapril only.