摘要
羟乙桂胺对麻醉猫胫前肌刺激性收缩具有显著松弛作用,并能明显消除盐酸吗啡所致小鼠的举尾现象。本品对于紫外线照射或sc角叉菜胶引起的足跖炎症或水肿均有良好的抑制作用。po15mg/kg和30mg/kg,小鼠的自主活动抑制率达78±42％和90±22％;保护士的宁引起小鼠致命性惊劂PD_(50)为112mg/kg,po小鼠的LD_(50)为1237mg/kg。
In anesthetized cats the musculus tibialis anterior, which waselectrically stimulated, was relaxed by 5 mg/kg idrocilamide. Idrocilamide inhibitedcatatonic rigidity of the mouse tail caused by injection of morphine, and also hadan anti-inflammatory effect against UV erythema and edema caused by carrageen-in rats.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1990年第2期70-72,共3页
Chinese Journal of Pharmaceuticals
关键词
羟乙桂胺
肌肉松弛剂
毒性
消炎
药理
idrocilamide
muscle relaxant
toxicity
anti-inflammatory
