摘要
在自行设计的多道穿梭测试系统内,使几个动物同步进行穿梭道音/电击条件性主动回避行为的学习试验,并固定药物总剂量,使一成分用量递减而另一成分相应增加。初步测得复合制剂中脑复康的含量减少时,仍出现同样程度的促智效应,而不出现胆碱的毒性。
The shuttle voice/shock conditional active avoidance test wasconducted with multiple-passage shuttle meter, using 100 mg/kg total dose withdifferent ratio of two components. The preliminary research in mice showedwhen in the piracetam (P) -chloine (C) preparation the ratio of P and C was 1:1or 1:4, the efficacy was approximately the same as the 100 mg/kg of P, andno toxicity of C was observed.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1990年第3期122-124,共3页
Chinese Journal of Pharmaceuticals
关键词
脑复康
胆碱
复合制剂
药理
piracetam
choline
combination optimization
shuttle voice/shock conditional active avoidance
learning
