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伊伐布雷定在心血管疾病中的研究进展 被引量：9

Advances in Using Ivabradine in Cardiovascular Disease
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摘要 伊伐布雷定为首个特异性心脏起搏电流抑制剂,具有特异性降低心率的作用,相关的动物实验及大规模临床研究也日益增多。现对伊伐布雷定在心血管疾病中的研究进展进行综述。 Ivabradine is the first cardiac pacing current（If current） inhibitor that specifically reduces heart rate.To date,there have been numerous ivabradine-related animal experiments and large clinical trials.This article reviews advances in using ivabradine in cardiovascular disease.
作者 李春雷 李竹琴 王岚峰
机构地区 哈尔滨医科大学附属第一医院心内科
出处 《心血管病学进展》 CAS 2012年第3期327-330,共4页 Advances in Cardiovascular Diseases
基金 黑龙江省教育厅(11521166)
关键词 伊伐布雷定 细胞 动物 临床 ivabradine cell animal clinic
分类号 R54 [医药卫生—心血管疾病]
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参考文献23

  • 1Rognoni A, Bertolazzi M, Maccio S, et al. Ivabradine: cardiovascular effects [Jl. Recent Pat Cardiovasc Drug Discov, 2009, 4( 1 ) :61-66.
  • 2Babu KS, Gadzik F, Holgate ST. Absence of respiratory effects with ivabradine in patients with asthma[ J]. Br J Clin Pharmacol, 2008, 66( 1 ) : 96-101.
  • 3刘燕平,王德才.新型抗心绞痛药伊伐布雷定[J].中国新药杂志,2008,17(19):1718-1720. 被引量：20
  • 4何跃辉,魏万林,张灵,孙竹.特异性降低心率药物——I_f抑制剂伊伐布雷定在心血管疾病中的应用研究进展[J].中国循证心血管医学杂志,2009,1(5):308-311. 被引量：7
  • 5Carom AJ, Lau CP. Eleetrophysiologieal effects of a single intravenous adminis- tration of ivabradine in adult patients with normal baseline eleetrophysiology[ J ]. Drugs R D, 2003, 4:83-89.
  • 6Manz M, Reuter M, Lauck G, et al. A single intravenous dose of ivabradine,a novel I(f) inhibitor,lowers heart rate but does not depress left ventricular func- tion in patients with left ventricular dysfunction [ J ]. Cardiology, 2003,100 : 149-155.
  • 7Colin O, Ghaleh B, Hittinger L, et al. Differential effects of heart rate reduc- tion and beta-blockade on left ventricular relaxation during exercise [ J ]. Am J Physiol Heart Circ Physiol, 2002,282 :H672-H679.
  • 8Riccioni G. Ivabradine : from molecular basis to clinical effectiveness [ J ]. Adv Ther, 2010, 27(3) :160-167.
  • 9Lappegard KT. Ivabradine and nightmares: a previously unreported adverse re- action[ J]. Eur J Cli, Pharmacol, 2009, 11 (suppi D) :D19-D27.
  • 10Bucchi A, Tognati A. Properties of ivabradine-induced block of HCN1 and HCN4 pacemaker channels [ J ]. J Physiol, 9006, 572 (2) :335-346.

二级参考文献53

  • 1TARDIF JC. Clinical efficacy of ivabradine[ J]. Heart Drug, 2005, 5(1): 25 -28.
  • 2NABEL EG, SELWYN AP, GANZ P. Paradoxical narrowing of atherosclerotic coronary arteries induced by increases in heart rate [J]. Circulation, 1990, 81(3): 850-859.
  • 3VATNER SF, BAIG H. Importance of heart rate in determining the effects of sympathomimetic amines on regional myocardial function and blood flow in conscious dogs with acute myocardial ischemia[J]. Circ Res, 1979, 45(6): 793 -803.
  • 4ROBERTO F, ANNA C, CLAUDIO C. Anti-ischaemic effect of ivabradine[J]. Pharm Res, 2006, 53(5): 435 -439.
  • 5BROWN HF, DIFRANCESCO D, NOBLE SJ. How does adrenaline accelerate the heart? [ J]. Nature, 1979, 280 (5719) : 235 -236.
  • 6DIFRANCESCO D. Characterization of singte pacemaker channels in cardiac sino-atrial node cells [ J]. Nature, 1986, 324 ( 6096 ) :470 - 473.
  • 7DIFRANCESCO D. The contribution of the "pacemaker" current (If) to generation of spontaneous activity in rabbit sino-atrial node myocytes[J].J Physiol, 1991, 434 (1) :23 - 40.
  • 8European Public Assessment Report (EPAR): Scientific discussion for Procoralan. London : EMEA, 2005 [ EB/OL ]. [ 2007 -11- 16]. http ://www. emea. eu. int.
  • 9BORER JS, FOX K, JAILLON P, et al. Antianginal and antiischemic effects of ivabradine, an If inhibitor, in stable angina: a randomized, double-blind, multicentered, placebo-controlled trial [ J ]. Circulation, 2003, 107 ( 6 ) : 817 - 823.
  • 10LOPEZ-BESCOS L, FILIPOVA S, MARTOS R. Long term safety and anti-anginal efficacy of the If current inhibitor ivabradine in patients with chronic stable angina. A one-year randomised, double blind multicentre trial[ J ]. Eur Heart J, 2004, (Abstract Suppl. ) :138[A876].

共引文献30

同被引文献97

  • 1李志勇.伊伐布雷定在慢性心衰中的应用[J].中国科技期刊数据库 医药,2016(7):120-120. 被引量：2
  • 2高照,李法琦.伊伐布雷定减慢心率的研究现状[J].心血管病学进展,2009,30(6):995-998. 被引量：11
  • 3李静,常改.西雅图量表测量冠心病患者生活质量的评价[J].中国公共卫生,2004,20(5):594-594. 被引量：114
  • 4沈绍功,姚金城.中医心病之心绞痛诊断与疗效标准[J].中国医药学报,2004,19(10):581-583. 被引量：126
  • 5无.慢性稳定性心绞痛诊断与治疗指南[J].中华心血管病杂志,2007,35(3):195-206. 被引量：2064
  • 6孙传兴.临床疾病诊断依据治愈好转标准(第2版)[M].北京:人民军医出版社,2006.77.
  • 7Qaseem A, Fihn SD, Williams S, et al. Diagnosis of stable ischemic heart disease: summary of a clinical practice guideline from the American College of Physicians/American College of Cardiology Foundation/A- merican Heart Association/American Association for Thoracic Surgery/ Preventive Cardiovascular Nurses Association/Society of Thoracic Sur- geons[J]. Annals of internal medicine, 2012, 157(10) : 729-734.
  • 8贺春晖.曲美他嗪治疗稳定型心绞痛的Meta分析[D].新疆医科大学,2012.贺春晖.
  • 9Borer JS, Fox K, Jailon P, et al. Antianginal and antiischemic effects of ivabradine, an ! (f) inhibitor, in stable angina : a randomized, double- blind, multicentered, placebo-controlled trial [ J ]. Circulation, 2003, 107(6) :817-823.
  • 10Tardif JC, Ford I, Tendera M. Efficacy of ivabradine, a new selective I (f) inhibitor, compared with atenolol in patients with chronicstable an- gina [ J 1. Eur Heart J,2005,26 ( 23 ) :2529-2536.

引证文献9

二级引证文献36

心血管病学进展
2012年 第3期

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