他汀类药物对室性心律失常的作用及机制研究

Effects and Mechanisms of Statins on Ventricular Arrhythmias

心脏性猝死是冠状动脉粥样硬化性心脏病患者的常见死因,而心脏性猝死大部分与致死性室性心律失常有关。大量研究表明他汀类药物可降低心血管疾病的发病率和病死率。令人注目的是大量的证据显示他汀类药物有抗室性心律失常的作用。他汀类药物可能通过增加副交感神经活性、改变跨膜离子通道的性质、修复粥样硬化斑块、稳定血小板、抗炎和抗增生作用、抗氧化作用、改善血管内皮功能、激活损害心肌、减轻因缺血导致的心肌细胞肥大等机制而有一定的抗室性心律失常的作用。

Sudden cardiac death is frequent among patients with coronary artery disease,and is related to life-threatening ventricular arrhythmias.Clinical and experimental evidence have demonstrated that therapeutic treatment using statins is significantly reduces cardiovascular morbidity and mortality.Compelling evidence from the majority of the studies reviewed shows that statins exhibit a protective effect against the occurrence of ventricular arrhythmias.The effects of statins against the occurrence of ventricular arrhythmias may be associated with mechanisms of decreasing parasympathetic tone,changing the properties of transmembrane ion channels,the regression of atherosclerotic plaques,stabilizing plaque,and many others.This review examines current research in the effects and mechanisms of treatments using statins on ventricular arrhythmias.