施普瑞对大鼠实验性肝纤维化的防治作用

Effects of Spirin in Prevention of Liver Fibrosis in Mice

为观察施普瑞对大鼠实验性肝纤维化的防治作用。采用40%CCl_4诱导大鼠肝纤维化。实验分为正常对照组、CCl_4组及施普瑞组。施普瑞组每公斤饲料加入螺施藻精粉50.4g。共12周。观察肝脏组织学,肝脏羟脯氨酸含量和血清Ⅲ型前胶原肽(PC—Ⅲ)及透明质酸(HA)水平。结果施普瑞组大鼠肝纤维化程度、PC—Ⅲ、HA水平及肝羟脯氨酸含量明显低于CCl_4组(P<0.05或<0.01)。结果提示施普瑞对实验性肝纤维化有防治作用。

To observe the effects of spirin(spirulina) in the prevention of liver fibrosis in mice. Wistra rat modelsof liver fibrosis were induced by 40% CC14 and 24 rats were divided into three groups:control group(n = 8),CCl4 group( n = 8),spirin group(n = g). Spirin group was given the feed with spirulina powder(50. 4g/kg feed) in all 12 weeks. Liver histological changes,hydroxyproline(HYP) content in Liver tissues,serum PC- Ⅱ and HA levels were observed. Spirin group had significantly lower levels of HYP,PC- Ⅲ and HA than those of CCl4 group. The pathological studies showed that the liver fibrosis of CCl4 group was more severe than that of spirin group. Spirin can prevent the formation of liver fibrosis.