动脉炎远期冠状动脉硬化发生的危险性

Premature atherogensis in the healed arteritis induced during the weaning period

目的 探讨川崎病远期冠状动脉硬化发生的危险性。方法 实验分为两组 :A组用马血清诱发兔的动脉炎 ,3mo后加用含 5 %胆固醇饲料喂养 ;B组未诱发动脉炎 ,饲料喂养同 A组 ,5 mo时两组取心脏做 HE和马森染色 ,观察冠状动脉的病理组织学变化 ,IBAS画像解析装置测算。结果 A组冠状动脉主干部内膜的肥厚、纤维性硬化以及心肌内冠状动脉的硬化程度均比 B组明显 (P<0 .0 5 )。

Objective To investigate the relationship between healed coronary arteritis and atherosclerosis induced by kawasaki disease. Methods [WT8.,7.75BZ]Rabbits of group A were induced the coronary arteritis by the double injection of horse serum.Group B were controls.At three months of age,these rabbits started to be fed with 5% cholesterol diet and were sacrificed two months later for the study of atherosclerotic lesion in the coronary artery with HE and Masson Trichrome staining Atherosclerotic lesion were graded as 0 to 3. Results Group A was significantly higher than group B in the severity of intimal thickening,stenosis and atherosclerotic lesion( P <0.05). Conclusion The persistent presence of intima lesion after arteritis may play an role in atherogensis.