脑瘫髋内收痉挛性内收肌组织化学和超微结构研究

Classication of muscles fibers and ultra structural study on adductor magnus muscles in children with spastic hip adduction from cerebral palsy

目的 研究小儿脑性瘫痪痉挛性髋内收肌肌纤维分型和肌细胞超微结构损害。方法 对 16例脑性瘫痪痉挛性髋内收患儿的内收大肌用肌球蛋白 ATP酶染色方法 ,对肌纤维进行分型和超微结构观察。结果 痉挛组内收大肌 型肌纤维 (慢缩纤维 )比例70 .92 % ,比对照组 (5 7.43% )明显增高 ,并可见同型肌纤维聚集。超微结构显示肌纤维内线粒体和肌纤维结构受到损害。结论 提示 型肌纤维增多和肌纤维的超微结构损害是脑瘫痉挛性髋内收手术治疗效果不佳的原因之一 ,引起肌纤维型改变的确切原因尚需进一步研究。

Objective To study ultrastructural damages and classification of types in muscles fibers in the adductor magnus muscles with spastic hipadduction of cerebral palsy. Methods Specimens of the adductor magnus muscles were ta ken from 16 surgically treated children with spastic hip adduction of cerebral palsy,histochemistry examined with muscles globulin ATP ase olye for the classification of muscles fibers and ultra structure also studied. Results The type I fibers,slow twitch fibers,were found to occupy a significantly higher ratio(70.92%)than controls( 57.93% ),and were often gathered to form type grouping.Ultra structural damages were found in all of the specimens. Conclusion It is suggested that these abnormalities are one of the factors a which cause spastic contraction of muscles without long term effects by surgical treatment.The reason which leads to transformation of the fiber types needs further investigation.