嗜麦芽窄食单胞菌感染的研究进展

Progress in sWnotrophomonas maltophilia

嗜麦芽窄食单胞菌是一种能导致难治性感染，并存在多种目前尚未明确的多重耐药的条件致病浦，尤其在免疫抑制患者中多见。尽管毒力不强，但由于其能在呼吸道上皮细胞和医疗器械表面定植，因此是住院患者的重要致病菌。同时，由于其对多种抗生素如碳青霉烯类天然耐药，以及对一线用药复方新诺明的耐药星升高趋势，目前对嗜麦芽窄食单胞菌感染的治疗受到了较大的挑战。近年来，嗜麦芽窄食单胞菌感染的预防和治疗备受关注。

Stenotrophomonas maltophilia （SMA） is a emerging opportunistic pathogen that can cause difficult-to-treat infections and exhibits significant degrees of poorly understood multidrug resistance, especially in immunocompromised patients . SMA is not an inherent virulent pathogen, but it can colonize in respiratorytract epithelial cells and surfaces of medical devices make it an important colonizer in hospitalized patients. Man- agement of SMA infection is hampered because of its high-level intrinsic resistance to many antibiotics and the increasing occurrence of acquired resistance to the first-line drug such as co-trimoxazole. The prevention and treatment of SMA infection attract more and more attention in recent years.