期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

药物代谢酶基因多态性与甲氨蝶呤治疗儿童急性淋巴细胞白血病不良反应 被引量：5

Association between the drug-metabolizing enzyme gene polymorphisms and toxicity of methotrexate in childhood acute lymphoblastic leukemia
原文传递
导出
摘要 随着白血病药物基因组学的研究进展，人们发现儿童急性淋巴细胞白血病药物代谢酶相关基因的多态性与不良反应相关。如何寻找有效预测甲氨蝶呤不良反应的基因型，进行个体化治疗是当前研究的热点。该文主要阐述三种药物代谢酶即亚甲基四氢叶酸还原酶、还原叶酸载体和谷胱甘肽S-转移酶基因多态性与甲氨喋呤相关不良反应之间的关系。 With advances on drug genomics of leukemia, the drug toxicity has been found to be associat- ed with the drug metabolism gene polymorphisms in children with acute lymphoblastic leukemia, Current researches are to focuse on how to find a genotype to predict methotrexate toxicity effectively and treat patients individually. This review illustrates the association between three drug-metabolizing enzyme gene polymorphisms including methylenetetrahydrofolate reductase,reduced folate carrier and glutathione S-transferase and toxicity of methotrexate.
作者 李红(综述) 蒋慧(审校)
机构地区 上海交通大学附属儿童医院、上海市儿童医院血液科
出处 《国际儿科学杂志》 2012年第3期274-276,共3页 International Journal of Pediatrics
关键词 基因多态性 急性淋巴细胞白血病 甲氨蝶呤 不良反应 儿童 Gene polymorphism Acute lymphoblastic leukemia Methotrexate Toxicity Children
分类号 R733.71 [医药卫生—肿瘤]
  • 相关文献

参考文献21

  • 1Irving J,Jesson J, Virgo P, et al. Establishment and validation of a standard protocol for the detection of minimal residual disease in B lineage childhood acute lymphoblastic leukemia by flow cytornetry in a multi-center setting. Haematologica,2009,94 ( 6 ) :870-874.
  • 2Huang L, Tissing W J, de JR, et al. Polymorphisms in folate-related genes: association with side effects of high-dose methotrexate in childhood acute lymphoblastic leukemia. Leukemia, 2008,22 ( 9 ) : 1798 -1800.
  • 3Vijayakrishnan J, Houlston RS. Candidate gene association studies and risk of childhood acute lymphoblastic leukemia: a systematic review and meta-analysis. Haematologica,2010,95 ( 8 ) : 1405-1414.
  • 4Ongaro A, De MM, Della Porta MG, et al. Gene polymorphisms in folate metabolizing enzymes in adult acute lymphoblastic leukemia: effects on methotrexate-related toxicity and survival. Haematologica, 2009,94 (10) : 1391-! 398.
  • 5Liu SG, Li ZG, Cui L, et al. Effects of methylenetetrahydrotblate reductase gene polymorphisms on toxicities during consolidation therapy in pediatric acute lymphoblastic leukemia in a Chinese population. Leak Lymphoma,2011,52 (6) : 1030-1040.
  • 6Imanishi H, Okamura N, Yagi M, et al. Genetic polymorphisms asso-ciated with adverse events and elimination of methotrexate in child- hood acute lymphoblastic leukemia and malignant lymphoma. J Hum Genet,2007,52(2) : 166-171.
  • 7Faganel KB, Grabnar I, Bohanec GP, et al. Association of genetic polymorphism in the folate metabolic pathway with methotrexate pharmacokinetics and toxicity in childhood acute lymphoblastic leu- kaemia and malignant lymphoma. Eur J Clin Pharmacol, 2011,67 (10) :993-1006.
  • 8Kantar M,Kosova B, Cetingul N, et al. Methylenetetrahydrofolate reductase C677T and A1298C gene polymorphisms and therapy-related toxicity in children treated for acute lymphoblastic leukemia and non- Hodgkin lymphoma. Leuk Lymphoma,2009,50(6) :912-917.
  • 9Tantawy AA, El-Bostany EA,Adly AA, et al. Methylene tetrahydro- folate reductase gene polymorphism in Egyptian children with acute lymphoblastic leukemia. Blood Coagul Fibrinolysis, 2010,21 ( 1 ) : 28 -34.
  • 10Karathanasis NV, Stiakaki E, Goulielmos GN, et al. The role of the methylenetetrahydrofolate reductase 677 and 1298 polymorphisms in Cretan children with acute lymphoblastic leukemia. Genet Test Mol Biomarkers,2011,15 ( 1-2 ) :5-10.

二级参考文献37

  • 1陆凤娟,吴玉霞,高怡瑾,陈超,金泰廙,金锡鹏,夏昭林.GST基因多态性与儿童白血病易感性的关系[J].环境与职业医学,2004,21(4):258-260. 被引量：7
  • 2顾龙君.儿童急性淋巴细胞白血病诊疗建议(第三次修订草案)[J].中华儿科杂志,2006,44(5):392-395. 被引量：479
  • 3Narawa T,Tsuda Y, Itoh T. Chiral recognition of amethopterin enantiomers by the reduced folate carrier in Caco- 2 cells[J ]. Drug Metab Pharmacokinet, 2007, 22(1) :33.
  • 4Laverdiere C, Chiass on S, Costea I, et al . Polymorphism G80A in the reduced folate carrier gene and its relationship to methotrexate plasma levels and outcome of childhood acute lymphoblastic leukemia[J]. Blood, 2002,100(10) : 3 832.
  • 5潘宏铭,徐农主编.肿瘤内科疾病临床治疗与合理用药[M].第1版.北京:科学技术文献出版社,2007:574.
  • 6Bosson G. Reduced folate carrier: biochemistry and molecular biology of the normal and methotrexate - resistant cell[J ] .Br J Biomed Sci, 2003, 60(2) : 117.
  • 7Matherly LH, Hou Z, Deng Y. Human reduced folate carrier: translation of basic biology to cancer etiology and therapy[J ] . Cancer Metastasis Rev,2007,26(1) : 111.
  • 8Chango A, Emery - Fillon N, Potier de Courcy G, et al. A polymorphism(80G- > A) in the reduced folate carrier gene and its associations with folate status and homocysteinemia[J]. Mol Genet Metab, 2000, 70(4): 310.
  • 9Whetstine JR, Gifford AJ, Witt T, et al. Single nucleotide polymorphisms in the human reduced folate carrier: characterization of a high - frequency G/ A variant at position 80 and transport properties of the His(27) and Arg(27) carriers[J]. Clin Cancer Res, 2001,7(11) :3 416.
  • 10Shimasaki N, Mori T, Samejima H, et al. Effects of methylenetetrahydrofolate reductase and reduced folate carrier 1 polymorphisms on high - dose methotrexate - induced toxicities in children with acute lymphoblastic leukemia or lymphoma[J] . J Pediatr Hematol Oncol, 2006,28(2) : 64.

共引文献15

同被引文献88

  • 1徐卫群,汤永民,方澄清,宋华,石淑文,扬世隆,任鼎泰,沈红强,钱伯芹.大剂量甲氨蝶呤治疗儿童急性淋巴细胞白血病排泄延迟分析[J].中华血液学杂志,2005,26(1):15-18. 被引量：66
  • 2Evans WE, Relling MV, Boyett JM, et al. Dose pharmacokinetlc variability influence the efficacy of hish-dose methotrexate for the treatment of children with acute lymphoblasfic leukemia:what can we learn from small studies. Leuk Res, 1997, 21:435--437.
  • 3Odoul F, Le Guellec C, Lamagnbre JP, et al. Prediction of metho- trexate elimination after high dose infusion in children with acute lymphoblastie leukemia using a population pharmacokinetie approach. Fundam Clin Pharmacol. 1999. 13: 595-604.
  • 4Joannon P, Oviedo I, Campbell M, et al. High-dose methotrexate therapy of childhood acute lymphoblastic leukemia: lack of relation between serum methotrexate concentration and creatinine clearance. Pediatr Blood Cancer, 2004, 43: 17-22.
  • 5Sorich M J, Pottier N, Pei D, et al. In vivo response to methotrexate forecasts outcome of acute lymphoblastic leukemia and has a distinct gene expression profile. PLoS Med, 2008,5 : e83.
  • 6Sktlrby TV, Anderson H, Heldrup J, et al. High leucovorin doses during high-dose methotrexate treatment may reduce the cure rate in childhood acute lymphoblastic leukemia. Leukemia, 2006, 20: 1955-1962.
  • 7Niemann A, Mtihlisch J, Frhwald ME, et al. Therapeutic drug monitoring of methotrexate in cerebrospinal fluid after systemic high-dose infusion in children: can the burden of intrathecal methotrexate be reduced? Tber Drug Monit, 2010, 32: 467-475.
  • 8PA TEL IN. Application of genotype-guided cancer therapy in solid tumors[J]. Pharmaeogenomies, 2014, 15 ( 1) : 79 - 93.
  • 9SHARMA SV, BELL DW, SETTLEMANJ, et al. Epidermal growth factor receptor mutations in lung cancer[J]. Nature Reviews Cancer, 2007,7(3) :169 -181.
  • 10SHI Y, AUJS, THONGPRASERT S, et al. A prospective, molecular epidemiology study of EGFR mutations in Asian patients with advanced non-small-cell lung cancer of adenocarcinoma histology (PIONEER)[J].J Thorae Oncol , 2014, 9(2) :154 -162.

引证文献5

二级引证文献28

国际儿科学杂志
2012年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部