内皮细胞损伤与慢性肾脏病关系的研究进展

Progress in the relationship of the endothelial dysfunction and chronic kidney disease

慢性肾脏病在病理上大多表现为间质炎症细胞浸润及纤维化，进而致肾功能进行性退化，最终不可避免地进展为终末期肾病。其中中晚期肾脏的进行性损害主要与肾间质微血管的丢失有关。鉴于肾间质微血管病变与慢性肾脏病的进展关系密切，该文从。肾间质微血管内皮细胞的损伤、修复及其干预策略三个层次综述其与慢性肾脏病的关系，旨在对慢性肾脏病的认识、干预及治疗有所裨益。

Most chronic kidney diseases are complicated by tubulointerstitial inflammation and fibrosis, leading to progressive deterioration of renal function, and potentially ultimately resulting in irreversible end-stage kidney. And the advanced tubulointerstitial damage is often associated with the lose of peritubular capillaries. With the close relationship of the lose of peritubular capillaries and the progress of chronic kidney diseases, this review reprents the relationship of endothelium and the progress of chronic kidney diseases through three levels including endothelial injury, repairment, and relative intervention, in order to aid in the recognition, intervention and therapy of chronic kidney diseases.