凝固酶阴性的葡萄球菌与早产儿脑损伤的关系

The relationship between coagulase-negative staphylococci and preterm brain injury

凝固酶阴性的葡萄球菌，尤其是表皮葡萄球菌（staphylococcusepidermidis，SE）存在于健康人的皮肤和黏膜上，它在医院内有高感染率，是重要的条件致病菌。SE是早产儿感染的最常见原因，这与早产儿大脑发育不成熟有关。流行病学研究支持早产儿、细菌感染和脑损伤之间存在相关性，SE可能是通过Toll样受体介导炎症反应而引起早产儿脑损伤。

Coagulase-negative staphylococci,especially staphylococcus epidermidis （SE） is on the sur- face of skin and mucous membrane of human, and because of its high frequency, especially in hospital, it is thought to be an important opportunistic pathogen. SE is the common cause of preterm infection, and it has rela- tionship with immature brain. Epidemiology supports the relationship among preterm,infection and brain injury. SE could lead to brain injury through Toll-like receptor mediated inflammation.