摘要
目的探讨不同严重程度支气管哮喘儿童诱导痰中白细胞介素（IL）-17的含量及中性粒细胞和嗜酸性粒细胞的百分比变化，揭示IL-17参与哮喘发病的可能机制。方法将40例急性发作期哮喘儿童依据哮喘严重度分为中重度组16例，轻度组24例，并选择健康体检儿童20例为正常对照组，检测所有儿童诱导痰中IL—17的含量和沉渣涂片中中性粒细胞和嗜酸性粒细胞的百分比。结果中重度组、轻度组和正常对照组的诱导痰中IL—17的含量分别是（1．096±0．664）ng／L、（0．474±0．240）ng／L、（0．227±0．360）ng／L，中性粒细胞百分比分别是（55．359±12．486）％、（44．476±17．708）％、（36．493±12．470）％，嗜酸性粒细胞百分比分别是（1．252±2．025）％、（4．107±3．234）％、（1．409±3．480）％，三组比较差异均有统计学意义（P〈0．05）。中重度组患儿中性粒细胞百分比与IL-17含量呈正相关（r：0．740，P=0．049），轻度组患儿中性粒细胞百分比与IL-17含量呈负相关（r=-0．764，P=0．000）。结论不同严重程度哮喘儿童IL-17含量、中性粒细胞和嗜酸性粒细胞百分比不同，IL-17参与了儿童哮喘的部分发病机制。
Objective To explore the changes of IL-17 and neutrophils, eosinophils percentage in the induced phlegm from the children with different severity bronchial asthma. Methods Forty children with acute asthma were divided into two groups according to the severity of asthma：medium or severe group（ n = 16 ） and light group （n = 24）. Twenty normal children were chosen in the same stage as control group. The IL-17 content and the percentage of neutrophils and eosinophils were compared. Results The contents of IL-17 in the medium or severe group, light group and control group were （ 1. 096 ± 0. 664 ）ng/L, （0. 474 ± 0. 240）ng/L and （0. 227 ± 0. 360） ng/L respectively. The percentage of neutrophils were（55. 359 ± 12. 486） % , （44. 476± 17. 708） % and （36. 493± 12. 470） % respectively. The percentage of eosinophils were（ 1. 252 ±2. 025） %, （4. 107±3.234） % and （ 1. 409± 3.480） % respectively. There were significant differences in three groups （ P 〈 0. 05 ）. There was significant positive correlation between IL-17 Content and percentage of neutrophils in the medium or severe group（ r = 0. 740, P = 0. 049 ）. There was negative correlation in the light group （ r = - 0. 764, P = 0. 000 ）. Conclusion There was different among IL-17 content and percentage of neutrophils, eosinophils in children of different groups. The study showed that IL-17 was involved in the potential pathogenesis of asthma.
出处
《国际儿科学杂志》
2012年第3期316-318,共3页
International Journal of Pediatrics
