丙种球蛋白治疗新生儿血小板减少性紫癜对血清B细胞激活因子的影响

Influence of gamma globulin to serum B cell activating factor in therapy of neonatal thrombocytopenic purpura

目的探讨丙种球蛋白在新生儿血小板减少性紫癜（NTP）治疗中对血清B细胞激活因子（BAFF）的影响。方法选取中山市中医院2009年10月至2011年9月收治的15例NTP患儿为治疗组，应用丙种球蛋白治疗，检测治疗组治疗前后及20例健康新生儿（对照组）血清BAFF的含量。结果治疗组治疗前血清BAFF水平为（0．96±0．48）μg/L，对照组为（0．48±0．35）μg／L，两组比较差异有统计学意义（P〈0．05）；治疗组治疗后血清BAFF水平为（0．45±0．37）μg/L，与治疗前比较差异有统计学意义（P〈0．05），与对照组比较差异无统计学意义。结论丙种球蛋白治疗新生儿血小板减少性紫癜的免疫抑制可通过减少BAFF产生而发挥作用。

Objective To study the influence of gamma globulin to serum B cell activating factor （BAFF） in therapy of neonatal thrombocytopenic purpura. Methods Fifteen cases with neonatal thrombocytope- nic purpura（treatment group） were treated with gamma globulin. Serum BAFF levels of treatment group before and after treatment and 20 healthy neonates （control group） were tested. Results Serum BAFF level of the treat- ment group before treatment was（0. 96 ± 0. 48 ） μg/L ,which was statistically significant compared with that of the control group[ （0. 48 ± 0. 35 ） μg/L] （ P 〈 0. 05 ）. Serum BAFF level of treatment group after treatment was （0. 45 ± 0. 37 ） μg/L, which was statistically significant compared with that of before treatment （ P 〈 0. 05 ）, but was not statistically significant compared with that of the control group. Conclusion Gamma globulin can play a role in the therapy of neonatal thrombocytopenic purpura by reducing the BAFF.