T2DM患者巨噬细胞移动抑制因子水平的变化及其意义

目的探讨2型糖尿病（T2DM）患者血浆巨噬细胞移动抑制因子（MIF）、基质金属蛋白酶-9（MMP-9）、高敏C-反应蛋白（hs-CRP）水平的变化及其意义。方法选取90例T2DM患者（观察组）和90例体检健康人（对照组）作血浆MIF、MMP-9、hs-CRP浓度测定（采用ELISA法）；同时测定空腹血糖（FBG）、糖化血红蛋白（HbAlc）、体重指数（BMll、血脂谱（TC、TG、LDL、HDL）、收缩压（sBP）、舒张压（DBP）。结果T2DM组MIF、MMP．9、hs—CRP水平明显高于对照组，差异有统计学意义（P〈0．05）。相关分析显示，MIF与BMI、MMP-9、hs—CRP呈正相关，与HDL呈负相关。结论MIF是T2DM的显著影响因子，在T2DM病变过程中起重要作用。检~T2DM患者MIF、MMP-9、hs—CRP水平有利于监测其病情、疗效评价及预防并发症。

Objective To study the change of serum macrophage migration inhibitory factor in type 2 diabetic patients and its significance. Methods 90 patients with type 2 diabetes mellitus were selected into observe group,and 90 normal subjects into control group.The plasma MIF, MMP-9 ~ hs-CRP concentration was measured by ELISA,additionally, fasting glucose（FBG）,HbAlc,body mass iudex,（BMI）,plasma lipids（TC, TG, LDL, HDL）,blood pressure（SBP, DBP） weice measured. Results The plasma MIF, MMP- 9, hs-CRP concentrations were significantly higher in T2DM group than in control group. MIF was significantly positively correlated with BMI, TC, TG, LDL, MMP-9,and was positively correlated with HDL.Conclusion MIF is a significantly effect factor of type 2 diabetes mellitus,and MIF plays an important role in the development of type 2 diabetes mellitus. Monitoring the plasma MIF, MMP- 9, hs-CRP level might be helpful in assessment of treatment efficacy and outcome predication.