托品酰胺扩瞳试验对早期老年性痴呆的筛查

The tropicamide pupil dilation test for preclinical Alzheimer's disease

目的 :探索老年性痴呆 (AD)早期的简易诊断方法。方法 :对 48例早期老年性痴呆病例和健康老年人用 0 .0 1%托品酰胺滴眼后动态观察扩瞳反应。结果 :AD轻异组扩瞳最大直径均值为 (5 .30± 1.0 1) m m明显大于健康组 (3.93±0 .5 6 ) mm (P <0 .0 0 5 )和 VD无 SAE组 (3.95± 0 .72 ) m m (P <0 .0 0 1)。但与 VD并 SAE组 (5 .15± 1.2 3) mm相比则无统计学显著性差异 (P >0 .0 5 )。结论 :托品酰胺扩瞳试验对 AD在高危人群中的早期发现有重要意义 ,可视为一种早期、无创伤、敏感易接受和推广的神经系统筛查方法。

Objective:To study a simple available diagnostic method for preclinical Alzheimer's disease Method:We observe 48 individuals for their pupil response to a 0 01% dilute solution of tropicamide The subjects were divided into three experimental groups:preclinical Alzheimer's disease(PAD),preclinical vascular dementia without SAE(PVD without SAE),preclinical vascular dementia with SAE(PVD with SAE) and control(healthy elderly) group A drop of a 0 01% tropicamide solution was adminstered to one eye and a drop of a control solution to the other eye Then observed the change of pupil diameter and the pupil diameter measurement were recorded in different time after drop Result:In PAD group the pupil maximally diameter was(5 36±1 01)mm more than the control group(3 93±0 56)mm(P<0 005) and PVD without SAE group(3 95±0 72)mm(P<0 001) Conclusion:It is suggested that the tropicamide pupil dilation test can be used as screening test for preclinical AD which cognitive founction is only slightly decline this is a early,simple noninvasion sensitive and easily administred diagnostic method for early AD