依那普利对大鼠环核苷酸的影响

EFFECT OF ENALAPRIL ON CYCLIC NUCLEOTIDE LEVELS IN RATS

依那普利(30mg/kg,口服)在降低SHR血压的同时改变大鼠血浆环核苷酸水平,iv对心电图无影响,但心率稍见减慢。正常大鼠iv血管紧张素Ⅰ后,血浆和肾脏环核苷酸含量均有显著改变。预先iv依那普利则对环核苷酸含量改变有完全或部分的抑制效应。这可能与依那普利抑制血管紧张素转化酶有关。

A fall of blood pressure was found 1h after administration of30 mg/kg enalapril via an intragastric tube in SHR. Enalapril increased theplasma cAMP and decreased the plasma cGMP and the cGMP/cAMP ratio signi-ficantly. After a high intravenous dose of enalapril, slight decrease of HR wasobserved, without other changes in ECG. After an iv injection of angiotensinⅠ(ANGI) to rats, the cGMP, cAMP, and cGMP/cAMP in plasma increasedsignificantly, but only the cAMP level in kidney was reduced. If a high iv doseof enalapril was given before the injection of ANGI, it could inhibit the effect ofANGI on the levels of cyclic nucleotides in both plasma and kidneys. Thisinhibitory effect might be related to its effect on ACE.