烧伤病人检测血清肌钙蛋白Ⅰ的临床意义

Clinical significance of serum cardiac troponin I in burn patients

目的 了解烧伤病人检测血清肌钙蛋白Ⅰ (cTnI)的临床意义。方法 5 5例烧伤病人于伤后 1天、2天、3天、5天、7天、1 4天、2 1天采血 ,用抗人心肌肌钙蛋白Ⅰ单抗 ,建立酶联法检测血清cTnI,同时检测肌酸激酶、肌酸激酶同功酶、乳酸脱氢酶和α 羟丁酸脱氢酶。结果 烧伤早期 ,有面部烧伤的病人 ,其cTnI值升高率达 6 0 %。创面感染和全身性炎症反应综合征时cTnI明显升高。结论 用抗人cTnI单抗检测血清cTnI可作为烧伤病人缺血性心肌损伤的灵敏的、特异性指标之一。

Objective To evaluate the clinical significance of serum cardiac troponin Ⅰ in burn patients.Methods Blood samples of fifty five burn patients were taken at 1,2,3,5,7,14,and 21 days postburn.We established a double monoclonal“sandwich” enzyme immunoassay to measure cardiac troponin Ⅰ in serum.Ck,CK MB,HBDH and LDH were measured at the same time.Results During early stage of burn,the serum cTnI increase rate was 60% in burn patients with face burn,the serum cTnⅠ increased markedly in patients with wound infection or systemic inflammatory response syndrome(SIRS).Conclusion A double monoclonal “sandwich” enzyme immunoassay to measure cardiac troponin Ⅰ might become a sensitive and specific marker to evaluate ischemic myocardiac injury after burns.