引起AECOPD精神神经症状原因及预防对策

Causes and prevention countermeasures of psychoneurosis induced by acute exacerbation of chronic obstructive pulmonary disease

目的探讨引起慢性阻塞性肺疾病急性加重期(AECOPD)精神神经症状原因及预防对策。方法分析2002年1月～2011年10月310例AECOPD患者的临床资料,根据动脉血气分析、电解质、头颅CT检查及治疗结果分析精神神经症状原因。结果 310例AECOPD患者合并精神神经症状40例(12.90%,40/310);肺性脑病22例(55.00%);低渗性脑病10例(25.00%);药物不良反应5例(12.50%);脑梗死3例(7.50%)。结论 AECOPD精神神经症状发生率较高,原因多样,应该进行鉴别诊断,实施针对性预防对策避免或减少其发生。

Objective To discuss the causes and prevention countermeasures of psychoneurosis induced by acute exacerbation of chronic obstructive pulmonary disease （AECOPD）. Methods The clinical data of patients with AECOPD from January 2002 to October 2011 were retrospectively analyzed including arterial blood gas analysis, electrolyte, head CT examination and treatment results in order to determine the causes of psychoneurosis. Results There were 40 （ 12. 90%, 40/310） cases with psychoneurosis in 310 AECOPD pa- tients, pulmonary encephalopathy in 22 cases （ 55.00% ）, and low permeability encephalopathy in 10 cases （ 25.00% ）. 5 patients （ 12. 50% ） had adverse drug reactions and cerebral infarction in 3 cases （7. 50% ）. Conclusions There were different reasons of psycho-neurosis induced by AECOPD with high incidence, which should be made the differential diagnosis. Reasonable prevention countermeas- ures should be taken to avoid or reduce its incidence.