545例住院结核病人耐多药现状分析

An Analysis of Multi-drug Resistance Trend on 545 Tuberculosis Inpatients

目的了解近年来滨州市住院结核病人的耐多药现状,为结核病的防控提供参考。方法以545例在滨州市结核病防治院住院的结核病人作为研究对象,分析其实验室及临床资料。结果 545例住院结核病人,初始耐药率16.3%,耐多药率3.6%,获得性耐药率24.8%,耐多药率17.2%,复治组耐多药率显著高于初治组,两组对比,均相差显著(P<0.01),有统计学意义,不规则用药是造成耐多药的主要因素。结论滨州市耐多药情况严重,需要严格执行结核病控制策略,加强方法学的研究,确保DOTS策略的实施,保证耐多药结核病人得到规范、有效的治疗管理,防止耐药菌株的产生和传播。

Objective To investigate multidrug resistance trend on tuberculosis inpatients in Bingzhou city,inorder to provide a reference for the prevention and control of tuberculosis.Method 545 cases of TB inpatients as the object of study,analysis of laboratory and clinical data.Results in 545 cases of multidrug resistant TB inpatient,initial drug resistance rate is 16.3%,resistance multidrug rate is 3.6%,and acquired drug resistance rate is 24.8%,resistance multidrug rate is 17.2%.Drug resistance rate in retreated group is significantly higher than that in the initialtreated group.Two sets of contrast,a significant difference（P0.01） is statistically significant.Multidrug-resistant is mainly caused by irregular medication.Conclusion Multidrug resistance is serious in TB inpationts in Binzhou City,which need strict implementation of the TB control strategy,the research methodology to ensure the implementation of the DOTS strategy,to ensure that multidrug TB patients are received standard and effective treatment management,to prevent the generation and dissemination of resistant strains.