90例药物不良反应报告分析

Analysis of 90 Cases of Adverse Drug Reactions

目的 :对北京 40 2医院 90例药物不良反应报告进行统计分析 ,以了解ADR的发生与性别、年龄和药物之间的关系。方法 :由临床医师、药师、护理人员发现并填写报告 ,经医院ADR监察小组专家分析评价。结果 :90例ADR中合并用药占总数的 5 1.1% ;涉及药物 5 5种 ,其中抗菌药物 2 1种引起ADR 40例占首位 ,12例是中药制剂引起 ,占总数的 13 .3 3 % ;ADR表现以皮肤及附件损害最多 ( 4 9例 ) ,严重的为急性肾功能衰竭导致死亡。结论 :应重视临床合理用药 ,避免和减少不良反应的发生 ,保障患者用药安全。

Objective:The reports of 90 cases of adverse drug reactions (ADRs) were statistically analyzed to investigate the relationship between ADR and sex, age, the used drugs. Methods:The cases of ADR were reported by physicians, pharmacists, and nurses, and then evaluated by the hospital ADR group. Results:46 out of the 90 cases (51.1 %) were treated with more than one drugs. 55 kinds of drugs were involved in. Among them, 21 were antibiotics in the first rank, 12 (13.33 %) were Chinese Medicines. ADR showed the lesion of skin and its annex (49 cases), mostly. Acute renal failure was a serious reaction and led to death finally. Conclusion:ADR could be decreased or avoided, if rational drugs were used for the patients.