摘要
目的观察肾炎舒胶囊联合厄贝沙坦治疗早期糖尿病肾病(diabetic nephropathy,DN)的临床疗效。方法将70例DN患者按随机数字表法随机分为对照组和治疗组,每组35例,对照组在基础治疗上予以厄贝沙坦口服,治疗组在对照组基础上加用肾炎舒胶囊。结果治疗组和对照组总有效率分别为91.43%和77.14%,差异无统计学意义(P>0.05)。治疗后治疗组尿微量清蛋白、24h尿蛋白及血清肌酐水平均比治疗前显著下降(P<0.01),且显著低于对照组(P<0.05,或P<0.01)。结论在DN的早期阶段应用肾炎舒胶囊联合厄贝沙坦治疗有明显疗效,且无不良反应。
Objective To observe the clinical effects of Shenyanshu Capsules, a patent traditional Chinese medicine for nephropathy, combined with irbesartan in the treatment of early diabetic nephropathy (DN). Methods A total of 70 patients with DN were randomly divided into two groups. Thirty five patients in the control group were trea- ted with conventional therapies and irbesartan; additionally, thirty-five patients in the treatment group were treated with Shenyanshu Capsules. Results The overall response rate in the treatment group and the control group was 91.4% and 77.1%, respectively. There was no significant difference in the overall response rate between the two groups (P〉0.05). After treatment, the levels of urinary microalbuminuria, 24-hour urinary alhumin, and serum creatinine were significantly decreased in the treatment group as compared with those before the treatment (P〈 0.01),and they were significantly lower than those in the control group (P〈0.05, or P%0.01). Conclusion She- nyanshu Capsules combined with irbesortan has significant effects in treating early DN,with no adverse effects.
出处
《安徽中医学院学报》
CAS
2012年第3期29-31,共3页
Journal of Anhui Traditional Chinese Medical College
关键词
早期糖尿病肾病
肾炎舒胶囊
厄贝沙坦
early diabetic nephropathy
Shenyanshu Capsules
irbesortan