川芎嗪注射液治疗不稳定型心绞痛疗效的Meta分析

Meta-analysis of ligustrazine injection in the treatment of unstable angina pectoris

目的系统的评价在常规用药基础上加用川芎嗪注射液治疗不稳定型心绞痛的疗效和安全性。方法采用循证医学方法,全面检索MEDLINE、Cochrane图书馆、CNKI、CBM、维普和万方数据库,纳入在常规治疗基础上加用川芎嗪注射液(试验组)对比常规(对照组)治疗不稳定型心绞痛的随机对照试验,对纳入研究进行偏倚分析,对同质性结果进行合并分析。结果共纳入12个试验,Meta分析结果显示,试验组和对照组临床症状疗效显效率和心电图疗效显效率都有显著性差异:RR=1.33,95%CI(1.12,1.58),P=0.01、RR=1.54,95%CI(1.16,2.05),P=0.003。结论基于目前临床证据,在常规治疗基础上加用川芎嗪注射液治疗不稳定型心绞痛疗效优于单纯常规治疗。

Objective It is to systematacially evaluate the effectiveness of compound ligustraxine injection in treatment of unstable angina pectoris（UAP） on the basis of normal therapy. Methods Databases of MEDLINE, the Cochrane Library, CNKI, CBM, VIP and Wanfang were searched by evidence based medicine method, randomized controlled trials （RCT） of treatment of UAP with ligustraxine injection （ experiment group） compared with treatment of UAP with normal therapy were collected. Bias risk of included RCTs was evaluated and homogeneity studies were meta-analyzed. Results 12 RCTs were gath- ered in tatal, meta-analysis results indicated that the difference in clinical symptoms excellent rate and electrocardiographic ex- cellent rate were significant between experiment group and control group. RR = 1.33, 95% CI（1.12, 1.58）, P =0.01, RR = 1.54, 95% CI（ 1.16, 2.05）, P = 0. 003. Conclusion Based on the recent clinical evidence, ligustraxine injection added to conventional therapy for the treatment of UAP is better than conventional treatment alone.