自然周期体外受精-胚胎移植在卵巢低反应患者中的应用价值

Clinical Value of Natural Cycle IVF-ET in Patients with Ovarian Low Response

目的:探讨自然周期体外受精-胚胎移植(IVF-ET)技术治疗卵巢低反应不孕患者的价值。方法:对2010年1月—2011年6月80例不孕症患者101个自然周期IVF-ET的临床资料进行回顾性分析;按是否获卵分为获卵组和未获卵组,分析其临床结局和影响因素。结果:101个取卵周期中,取卵周期获卵率77.2%,取卵周期胚胎移植率56.4%,取卵周期妊娠率16.8%,获卵周期妊娠率21.8%,移植周期临床妊娠率29.8%。获卵组人绒毛膜促性腺激素(hCG)日黄体生成激素(LH)值明显低于非获卵组,差异有统计学意义(P<0.05)。结论:对于卵巢低反应患者,采用自然周期IVF-ET是一种简单、经济、有效的方法;hCG日LH值是影响自然周期获卵的重要因素。

Objective：To evaluate the application of natural-cycle in vitro fertilization-embryo transfer （IVF-ET） in infertile women with ovarian low response. Methods ：The retrospective analysis was designed. The natural-cycle IVF-ET was applied in 80 infertile women with ovarian low response in Reproductive Medicine Center,Tianjin Central Hospital for Obstetrics and Gynecology, from January 2010 to June 2011. Patients were divided into two groups according to obtaining oocytes or not. Results ：102 oocytes-retrieved cycles were performed in 80 cases. The obtained oocytes rate, embryo transfer rate and pregnancy rate in oocytes-retrieved cycles,the pregnancy rate in the obtained-oocytes cycles and clinical pregnancy rate in embryos transferred cycles were 77.2%,56.4%, 16.8%,21.8% and 29.8%,respectively. LH values on the day of hCG administration in the obtained oocytes group was significantly higher than that in another group （P〈0.05）. Conclusions： Natural-cycle IVF-ET is a simple, effective and economic therapeutics for patients with ovarian low response. LH values on the day of hCG administration may have a predicting value for obtaining oocytes.