期刊文献+

阿司匹林抵抗与血瘀 被引量:1

Aspirin Resistance and Blood Stasis
下载PDF
导出
摘要 阿司匹林通过不可逆抑制血栓素A2生成,在心脑血管疾病防治中发挥着重要作用。部分患者存在阿司匹林抵抗现象,解决阿司匹林抵抗已被广泛关注。研究证实:阿司匹林抵抗与临床事件发生具有相关性。通过对阿司匹林抵抗与血瘀证关系研究,认为血瘀证可能是阿司匹林抵抗的中医发病机制之一。希望发挥中医中药辨证论治和整体调节的优势,结合现代医学,针对不同的群体进行AR产生机制及防治方面的研究,使阿司匹林抵抗问题得到较好的解决,从而为心脑血管疾病的治疗预防带来更大的益处。 Aspirin through irreversible inhibition of thromboxane A2 production, in the cardiovascular and cerebrovascular diseases plays an important role in. But some patients have the phenomenon of aspirin resistance, study confirmed aspirin resistance and clinical events with correlation. Based on the relationship of blood stasis syndrome and aspirin resistance research, hoping to play traditional Chinese medicine syndrome differentiation and overall regulation of advantage, combined with modern medicine, for different groups of AR generation mechanism and control research of aspirin resistance, so that the problems are better resolved, thus for cardiovascular and cerebrovascular diseases prevention and treatment to bring greater benefits.
作者 赵军伟
机构地区 成都中医药大学
出处 《实用中医内科杂志》 2012年第5期65-66,共2页 Journal of Practical Traditional Chinese Internal Medicine
关键词 阿司匹林抵抗 血瘀 血栓素A2 中西医结合研究 Aspirin resistance Blood stasis Thromboxane A2 Traditional Chinese combined with Western medicine research
  • 相关文献

参考文献9

  • 1ISIS -2 ( Second International Study of Infarct Survival) Collaborative Group, Randomised trial of intravenous strep tokinase, oral aspirin, both, or neither among 17 187 cases of suspected acute myocardialinfarction: ISIS-2 Lancet, 1988, 332:349-360.
  • 2KAWASA KIT , OZEKI Y, IGAWA T , et al. Increased platelet sensitivity to collagen in individuals restant to low - dose aspirin [ J ]. St roke ,2000,31:591 -594.
  • 3ANDERSEN K, HURL EN M , AMESEN H , et al. Aspirin non - responsiveness as measured by PFA - 100 in patients with coronary artery disease [ J ]. Thromb Res.2002,108:37 - 42.
  • 4FRANCESCO C , GIOVANNI C , PAOLA P, et al. Oxidant stress and aspirin - insensitive thromboxane, biosynthesis in severe unstable angina [J]. Circulation ,2000 , 102 : 1007 - 1010.
  • 5Bhatt DL1 Aspirin resistance: more than just a laboratory JAm Coil Cardiol, 2004,43 : 1127 - 1129.
  • 6Wang TH, Bhatt DL, Topoi EJ Aspirin and elop idogrel resistance: an emerging clinical entity Eur Heart J ,2006,27:647 -654.
  • 7李彬,毛静远,王强,张运,张其梅,郑颖.三七总苷对阿司匹林抵抗影响的临床观察[J].中西医结合心脑血管病杂志,2007,5(7):579-581. 被引量:18
  • 8刘泉坤,王庄,谢均,刘敏,邹伟华.银杏叶片治疗阿司匹林抵抗的临床对照研究[J].浙江中医杂志,2010,45(5):320-322. 被引量:15
  • 9刘红权.逐瘀通脉胶囊治疗阿司匹林抵抗临床观察[J].辽宁中医药大学学报,2008,10(7):109-110. 被引量:7

二级参考文献36

  • 1赵保路.银杏叶提取物抗氧化和防治心脑血管疾病的作用机制研究[J].中华老年心脑血管病杂志,2000,2(1):65-68. 被引量:30
  • 2苏雅,赵益桂,张宗鹏,岳南.三七三醇皂甙对动物血小板功能及血栓形成的影响[J].中草药,1996,27(11):666-669. 被引量:55
  • 3中华神经科学会.脑血管疾病分类、诊断要点、神经功能缺损评分标准[J].中华神经科杂志,1996,29(6):376-376.
  • 4[1]Rosamond WD,Folsom AR,Chambless LE,et al.Stroke incidence and survival among middle-aged adults:9-year follow-up of the Atherosclerosis Risk in Communities (ARIC) cohort[J].Stroke,1999,30:736-743.
  • 5[2]Tran H,Anand SS.Oral anfiplatelet therapy in cerebrovascular disease,coronary artery disease,and peripheral arterial disease[J].JAMA,2004,292:1867-1874.
  • 6[3]Hankey GJ,Eikelboom JW.Aspirin resistance[J].BMJ,2004,328:477-479.
  • 7[5]Antithrombotic Trialists' Collaboration.Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death,myocardial infarction,and stroke in high risk patients[J].BMJ,2002,324:71-86.
  • 8[6]Friend M,Vucenik I,Miller M.Research pointers:Platelet responsiveness to aspirin in patients with hyperlipidaemia[J].BMJ,2003,326:82-83.
  • 9[7]Cambria-Kiely JA,Gandhi PJ.Possible mechanisms of aspirin resistance[J].J Thromb Thrombolysis,2002,13:49-56.
  • 10[8]Gum PA,Kottke-Marchant K,Welsh PA,et al.A prospective,blinded determination of the natural history of aspirin resistance among stable patients with cardiovascular disease[J].J Am Coil Cardiol,2003,41:961-965.

共引文献31

同被引文献20

引证文献1

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部