摘要
目的:探讨白三烯在肺炎支原体(MP)感染发病机制中的作用。方法:收集住院确诊为MP感染的60例患儿为MP感染组,其中轻度感染10例,中度感染31例,重度感染19例。另选择同期门诊正常健康体检的60名儿童为正常对照组。用双抗体夹心ELISA法检测两组儿童血清白三烯B4(LTB4)和尿白三烯E4(LTE4)水平。结果:MP感染组血清LTB4及尿LTE4的水平均明显高于正常对照组(P均<0.01)。MP感染患儿血清LTB4的水平和尿LTE4的水平呈正相关(r=0.522,P<0.01),且均与MP感染的病情呈正相关(rs分别为0.617、0.567,P均<0.01)。结论:MP感染患儿的血清LTB4、尿LTE4水平均明显升高,并且血清LTB4、尿LTE4与MP感染病情有关,白三烯在MP感染的发病机制中可能起重要作用。
Objective: To investigate the roles of leukotrienes in the children with MP infection. Methods: Sixty children with MP infection in clinic were enrolled into MP infection group, and assigned into, they were di- vided into mild infection group (n = 10) , median infection group (n = 31 ) and severe infection group (n = 19), according the severity. Sixty healthy children in routing physical examinations in outpatient department were select- ed as normal controls. Serum leukotriene B4 (LTB4) and urine leukotriene (LTE4) were assessed by ELISA. Results: Significantly higher serum LTB4 and urine LTE4 were revealed in the MP infection group than those in normal control group (P 〈 0. 01 ). There was significantly positive correlation revealed between the serum LTB4 and the urinary LTE4 in the MP infection group (r =0. 522, P 〈0.01 ). There were also significantly positive cor- relation between the serum LTB4 or urinary LTE4 and the severity of MP infection ( rs = 0. 617 and 0. 567, P 〈 0. 01 ). Conclusion: LTB4 and LTE4 are elevated in the MP infection and positively correlated with the severi- ty of MP infection, suggesting that they play important roles in MP infection.
出处
《新医学》
2012年第5期294-297,共4页
Journal of New Medicine
基金
广东江门市卫生系统科研立项(06A054)
关键词
肺炎支原体
感染
白三烯
Mycoplasma pneumoniae
Infection
Leukotriene