肺炎支原体感染患儿白三烯的水平变化及临床意义——附60例分析

Clinical significance on change of leukotrienes in children with mycoplasma pneumoniae infection:Analysis of 60 cases

目的:探讨白三烯在肺炎支原体(MP)感染发病机制中的作用。方法:收集住院确诊为MP感染的60例患儿为MP感染组,其中轻度感染10例,中度感染31例,重度感染19例。另选择同期门诊正常健康体检的60名儿童为正常对照组。用双抗体夹心ELISA法检测两组儿童血清白三烯B4(LTB4)和尿白三烯E4(LTE4)水平。结果:MP感染组血清LTB4及尿LTE4的水平均明显高于正常对照组(P均<0.01)。MP感染患儿血清LTB4的水平和尿LTE4的水平呈正相关(r=0.522,P<0.01),且均与MP感染的病情呈正相关(rs分别为0.617、0.567,P均<0.01)。结论:MP感染患儿的血清LTB4、尿LTE4水平均明显升高,并且血清LTB4、尿LTE4与MP感染病情有关,白三烯在MP感染的发病机制中可能起重要作用。

Objective： To investigate the roles of leukotrienes in the children with MP infection. Methods： Sixty children with MP infection in clinic were enrolled into MP infection group, and assigned into, they were di- vided into mild infection group （n = 10） , median infection group （n = 31 ） and severe infection group （n = 19）, according the severity. Sixty healthy children in routing physical examinations in outpatient department were select- ed as normal controls. Serum leukotriene B4 （LTB4） and urine leukotriene （LTE4） were assessed by ELISA. Results： Significantly higher serum LTB4 and urine LTE4 were revealed in the MP infection group than those in normal control group （P 〈 0. 01 ）. There was significantly positive correlation revealed between the serum LTB4 and the urinary LTE4 in the MP infection group （r =0. 522, P 〈0.01 ）. There were also significantly positive cor- relation between the serum LTB4 or urinary LTE4 and the severity of MP infection （ rs = 0. 617 and 0. 567, P 〈 0. 01 ）. Conclusion： LTB4 and LTE4 are elevated in the MP infection and positively correlated with the severi- ty of MP infection, suggesting that they play important roles in MP infection.