生姜陈皮汤对顺铂所致水貂呕吐模型的治疗作用

Antiemetic effect of citrus ginger soup on cisplatin-induced vomiting in minks

目的研究生姜陈皮汤对顺铂所致水貂呕吐模型的治疗作用。方法雄性水貂随机分为5组:正常对照组、模型对照组、昂丹司琼组、生姜陈皮汤低剂量组和高剂量组,各组分别给予生理盐水、生理盐水、昂丹司琼、生姜陈皮汤低剂量和高剂量处理两天,第2天处理后30 min除正常对照组外各组水貂给予腹腔注射顺铂,观察注射顺铂后6 h内水貂呕吐潜伏期,干呕及呕吐次数。结果与模型组比较,生姜陈皮汤高、低剂量组和昂丹司琼组均能显著延长呕吐潜伏期(P<0.05,P<0.01),并明显减少干呕及呕吐次数(P<0.01)。结论生姜陈皮汤对顺铂所致的水貂呕吐具有治疗作用。

Objective： To investigate the therapeutic effect of citrus ginger soup on cisplatin - induced vomiting in minks. Methods： Male minks were divided into 5 groups： the blank control, model control, ondansetron, low dose citrus ginger soup and high dose citrus ginger soup groups. The minks in every group were administrated saline, saline, ondanse- tron, low dose citrus ginger soup and high dose citrus ginger soup respectively for 2 days. In addition to the normal control group, cisplatin was injected to each group in the second day about 30 minutes later after the administration. The latency and the times of retching and vomiting episodes were recorded in the following 6 hours. Results ： Compared to the model control group, the latency of low dose and high dose citrus ginger soup groups were longer significandy （ P 〈 0.05, P 〈 0. 01）, the times of retching and vomiting episodes decreased significantly （all P 〈 0.01 ）. Conclusion： The citrus ginger soup shows an antiemetic effect on cisplatin - induced vomiting in minks.